Evaluating the elasticity of the mitral valve in living humans
Evaluation of the Elasticity of the Mitral Valve Chordae by Uniaxial Traction in the Context of Mitral Valve Regurgitation With a Comparison of the Results: Mitral Valve Prolapse vs Restriction of Mitral Valve Movement
Centre Hospitalier Universitaire de Saint Etienne · NCT06153563
This study is trying to see how stretchy the mitral valve chords are in people who need mitral valve replacement, comparing those with mitral valve prolapse to those with a different heart condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 45 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne (other) |
| Locations | 1 site (Saint-Etienne) |
| Trial ID | NCT06153563 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the mechanobiological and histological characteristics of mitral valve chords in living humans, a topic that has not been previously explored in the literature. The study will involve 20 patients scheduled for mitral valve replacement, who will be grouped based on their specific mitral valve conditions. Data will be collected on patient history and intraoperative results, with a focus on comparing the elasticity of mitral valve chords between patients with mitral valve prolapse and those with restrictive ischemic mitral valve. The harvested tissue will be preserved in natural conditions to ensure accurate analysis.
Who should consider this trial
Good fit: Ideal candidates for this study are patients over 45 years old scheduled for mitral valve replacement.
Not a fit: Patients with mitral calcification, rheumatic disease, infections, or those undergoing redo surgery on the mitral valve may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of mitral valve disease and improve surgical outcomes for patients undergoing mitral valve replacement.
How similar studies have performed: This study addresses a novel area of research, as previous examinations have primarily focused on animal tissues or frozen human samples, making it an untested approach in living humans.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: All patients programmed for mitral valve replacement who have more than 45 years old Exclusion Criteria: * Patients with mitral calcification * Mitral valve rheumatic disease * Mitral valve infections * Redo surgery on the mitral valve
Where this trial is running
Saint-Etienne
- CHU Saint-Etienne — Saint-Etienne, France (RECRUITING)
Study contacts
- Principal investigator: Andranik PETROSYAN, MD — Centre Hospitalier Universitaire de Saint Etienne
- Study coordinator: Andranik PETROSYAN, MD
- Email: andranik.petrosyan@chu-st-etienne.fr
- Phone: (0)477829505
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Mitral Valve Disease, Mitral valve, mitral valve chords, elasticity, Young's modulus, mitral valve histology