How bone changes in response to primary and metastatic cancer
Official title: Role of Bone in Primary and Metastatic Cancer
Funded at Washington University · NIH-10880414 · Data updated 2026-11-12
This study looks at how a primary breast tumor changes the bone environment and affects immune and bone cells before cancer spreads, with the goal of finding new ways to improve treatment for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $342,268 |
| NIH project number | 5R01CA235096-05 |
| Project ID | NIH-10880414 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with stage II-III breast cancer who are undergoing treatment.
✕Less likely to help
Patients with cancers that do not involve the bone or those who are in advanced stages of cancer may not benefit from this research.
What this research studies
This research investigates how the presence of a primary tumor alters the bone microenvironment, affecting both immune and bone cells. It focuses on the early changes that occur in the bone before any cancer spreads, particularly in breast cancer patients. The study examines the role of specific cells and signaling pathways in the bone that may influence tumor growth and spread. By analyzing these interactions, the research aims to uncover potential therapeutic targets for improving cancer treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer spread and improving treatment for patients with breast cancer.
How similar studies have gone: Other research has shown promising results in understanding the role of the bone microenvironment in cancer progression, indicating that this approach has potential for significant findings.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Faccio, Roberta — Washington University
- Study coordinator: Faccio, Roberta
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.