Condition

Locally Advanced Solid Tumor clinical trials and research

• 16Clinical trials
• 16Countries

Newest Locally Advanced Solid Tumor clinical trials

All recruiting trials (16)

• 5-Azacitidine with PD-1/PD-L1 Inhibitor in PD-1/PD-L1 Refractory Tumors

  This phase I study tests different doses of 5-azacitidine combined with a PD-1/PD-L1 blocker to see if the combo can help patients whose tumors no longer respond to PD-1/PD-L1 therapy.

  Recruiting Phase 1 University of Iowa · Iowa City, Iowa · NCT07404332

• Safety and anti-tumor activity of IPN60300 in adults with advanced or metastatic solid tumors

  This trial will test whether injections of IPN60300 are safe and can help control advanced or metastatic solid tumors in adults.

  Recruiting at 10 sites Phase 1/2 Ipsen · New Haven, Connecticut and 11 other locations · NCT07213817

• YH32364 for locally advanced or metastatic EGFR‑overexpressing solid tumors

  This trial will test whether YH32364 can help adults with advanced or metastatic cancers that overexpress EGFR when other treatments haven't worked.

  Recruiting at 4 sites Phase 1/2 Yuhan Corporation · Seoul and 3 other locations · NCT06975410

• Evaluating VC004 for patients with advanced solid tumors

  This study is testing a new medication called VC004 to see if it helps people with advanced solid tumors feel better and manage their condition.

  Recruiting Phase 3 Jiangsu vcare pharmaceutical technology co., LTD · Beijing, Beijing Municipality · NCT06658353

• Imaging of immune response in advanced solid tumors

  This study is testing a new imaging method to see how well it can track the immune response in people with advanced solid tumors who are receiving PD-1 antibody treatments.

  Recruiting at 2 sites Phase 2 University Medical Center Groningen · Amsterdam and 3 other locations · NCT06534190

• Evaluating NVL-330 for advanced HER2-altered lung cancer

  This study is testing a new treatment called NVL-330 to see if it can safely help people with advanced lung cancer that has changes in the HER2 gene.

  Recruiting at 20 sites Phase 1 Nuvalent Inc. · Irvine, California and 20 other locations · NCT06521554

• Lattice radiation therapy for treating large tumors

  This study is testing a new type of radiation therapy called lattice radiation therapy to see if it works better than standard treatment for people with large tumors.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT06416007

• Treatment of advanced solid tumors using ACE2016 cell therapy

  This study is testing a new cell therapy called ACE2016 to see if it can help people with advanced solid tumors that have not improved with other treatments.

  Recruiting at 4 sites Phase 1 Acepodia Biotech, Inc. · San Diego, California and 8 other locations · NCT06415487

• Using topical tretinoin to prevent skin issues from cancer treatment

  This study is testing if a cream called tretinoin can help reduce skin rashes for patients with metastatic colorectal cancer who are receiving certain cancer treatments.

  Recruiting Phase 2 University of Utah · Salt Lake City, Utah · NCT06358677

• Testing IBI3001 in patients with advanced solid tumors

  This study is testing a new treatment called IBI3001 to see if it can help people with advanced solid tumors who haven't had success with other therapies.

  Recruiting at 26 sites Phase 1 Fortvita Biologics (USA)Inc. · Los Angeles, California and 26 other locations · NCT06349408

• Testing a new treatment for advanced cancer using a radiolabeled drug

  This study is testing a new drug for adults with advanced cancer who have run out of other treatment options to see if it is safe and how well it works.

  Recruiting at 2 sites Phase 1/2 Spago Nanomedical AB · Adelaide, South Australia and 1 other locations · NCT06184035

• Evaluating mutations in solid tumors using liquid biopsy and genome sequencing

  This study is trying to see if a blood test can find important gene changes in patients with advanced solid tumors to help doctors choose the best treatments for them.

  Recruiting Centro di Riferimento Oncologico - Aviano · Aviano, Pordonone · NCT06028724

• FOG-001 treatment for advanced or metastatic solid tumors

  This study is testing a new drug called FOG-001 to see if it can help people with advanced solid tumors, especially those with certain genetic changes, when traditional treatments aren't working.

  Recruiting at 32 sites Phase 1/2 Parabilis Medicines, Inc. · Phoenix, Arizona and 32 other locations · NCT05919264

• Testing TNG462 for patients with specific solid tumors

  This study is testing a new drug called TNG462 to see if it can safely help people with advanced solid tumors that have a specific genetic change.

  Recruiting at 25 sites Phase 1/2 Tango Therapeutics, Inc. · Palo Alto, California and 25 other locations · NCT05732831

• Evaluating NVL-655 for Advanced ALK-Positive Solid Tumors

  This study is testing a new drug called NVL-655 to see if it can safely help people with advanced ALK-positive solid tumors, including non-small cell lung cancer.

  Recruiting at 73 sites Phase 1/2 Nuvalent Inc. · Orange, California and 73 other locations · NCT05384626

• Evaluating NVL-520 for Advanced ROS1-positive Solid Tumors

  This study is testing a new drug called NVL-520 to see if it can safely help people with advanced solid tumors that have a specific genetic change called ROS1.

  Recruiting at 58 sites Phase 1/2 Nuvalent Inc. · Orange, California and 62 other locations · NCT05118789

Related topics

Quick answers

How many Locally Advanced Solid Tumor clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (11 trials), Australia (6 trials), Spain (5 trials), France (4 trials), South Korea (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 7, Phase 1: 4, Phase 2: 3, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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