Understanding how certain proteins are released in metastatic cancer
Official title: Novel molecular mechanism for extracellular release of proteins implicated in metastatic cancer
Funded at Saint Louis University · NIH-10880671 · Data updated 2026-11-12
This study is looking at how certain proteins are released from cells in unusual ways when they are under stress, like in cancerous tumors, to find new treatment options that could help improve care for cancer patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $394,314 |
| NIH project number | 5R37CA265877-03 |
| Project ID | NIH-10880671 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with metastatic cancer, particularly those experiencing hypoxic conditions.
✕Less likely to help
Patients with early-stage cancer or those not experiencing cellular stress may not benefit from this research.
What this research studies
This research investigates how specific proteins, which play crucial roles inside and outside of cells, are released through unconventional pathways rather than the typical secretion routes. It focuses on how these pathways are activated during cellular stress, such as in hypoxic conditions found in metastatic tumors. By exploring the molecular mechanisms that regulate the release of these proteins, the research aims to uncover new therapeutic strategies that could improve treatment outcomes for cancer patients. The study employs advanced techniques to analyze the interactions between proteins and cellular membranes under various conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better control protein release in cancer, potentially improving treatment effectiveness.
How similar studies have gone: While the specific mechanisms being studied may be novel, similar research has shown promise in understanding protein secretion pathways in cancer.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Dastvan, Reza — Saint Louis University
- Study coordinator: Dastvan, Reza
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.