Condition

Male Infertility clinical trials and research

• 15Clinical trials
• 9NIH research projects
• 10Countries

Newest Male Infertility clinical trials

All recruiting trials (15)

• Correlation between PLC zeta measurements and semen parameters in male infertility

  This study tests whether levels of the sperm protein PLCζ in semen relate to standard semen quality measures in men facing infertility.

  Recruiting Fakih IVF Fertility Center · Abu Dhabi and 1 other locations · NCT07684339

• Single infrapubic versus bilateral subinguinal microsurgical varicocelectomy for bilateral varicocele

  This trial tests whether a single infrapubic approach can fix both varicoceles more quickly and with less pain than the standard two-incision bilateral approach in men with infertility.

  Recruiting Beni-Suef University · Banī Suwayf, Beni Suweif Governorate · NCT07650955

• Live motile sperm sorting device vs standard sperm prep in older men for IVF outcomes

  This study tests whether the LensHooke CA0, a centrifugation-free sperm sorting method, improves IVF outcomes for couples where the male partner is 40 or older.

  Recruiting Vietnam Military Medical University · Hà Nội, Ha Dong · NCT07605182

• AI tool to analyze sperm and predict their ability to help IVF/ICSI succeed

  This project will test an AI platform that analyzes semen samples from men providing sperm for IVF/ICSI to see if it can predict which samples have the best chance of supporting successful IVF/ICSI outcomes.

  Recruiting at 5 sites Fecundis Lab SL · Barcelona, Barcelona and 4 other locations · NCT07456397

• Daily gazpacho to improve semen quality in men with reduced sperm parameters

  This study will test whether drinking a daily 330 mL serving of gazpacho for 12 weeks helps men with reduced sperm quality improve their semen parameters and lower oxidative stress.

  Recruiting Ginefiv · Madrid, Madrid · NCT07375238

• Probiotics to improve sperm count, motility, and morphology in men with low sperm quality

  This study tests whether daily probiotic supplements can improve sperm count, motility, and morphology in men with unexplained low sperm quality.

  Recruiting Mackay Memorial Hospital · New Taipei City · NCT07345455

• Royal Jelly to Help Unexplained Male Infertility

  A randomized, placebo-controlled study tests whether daily royal jelly can improve sperm DNA integrity and help couples achieve pregnancy when the man’s fertility appears normal by standard tests.

  Recruiting Medipol University · Istanbul, Başakşehir · NCT07337265

• Evaluating a new sperm-wash device for improving intrauterine insemination outcomes in infertile couples

  This study is testing a new sperm-wash device to see if it can help infertile couples have a better chance of getting pregnant through intrauterine insemination.

  Recruiting Chung Shan Medical University · Taichung, Taichung City · NCT06956287

• Biobank for male infertility specimens

  This study is collecting leftover sperm and tissue samples from men who have had fertility treatments to help improve understanding and treatment of male infertility in the future.

  Recruiting Reproductive Medicine Associates of New Jersey · Basking Ridge, New Jersey · NCT06880302

• Evaluating a new method for sperm capacitation

  This study is testing a new method called HyperSperm to see if it can improve sperm quality for men who are having trouble with fertility.

  Recruiting at 4 sites Fecundis Lab SL · Barcelona, Barcelona and 3 other locations · NCT06742437

• Comparing live birth rates after ICSI with artificial oocyte activation versus ICSI alone for severe teratospermia

  This trial tests whether adding artificial oocyte activation (AOA) to intracytoplasmic sperm injection (ICSI) helps couples with severe teratospermia have higher live birth rates.

  Recruiting ShangHai Ji Ai Genetics & IVF Institute · Shanghai · NCT06561451

• Testing a marine product for treating male infertility

  This study is testing a marine product to see if it can improve semen quality in men aged 18 to 45 who have been struggling with infertility.

  Recruiting Fitoplancton Marino, S.L. · Barcelona · NCT06324071

• Observational study on the quality of life of outpatients with urologic diseases

  This study looks at how urologic diseases affect the quality of life for outpatients to see how their treatment and overall health can be improved.

  Recruiting IRCCS San Raffaele · Milan, Lombardy · NCT06193850

• Using platelet rich plasma to treat infertility in men

  This study is testing if using platelet-rich plasma injections can help men with infertility, specifically those who have had trouble retrieving sperm, improve their chances of successful sperm extraction and IVF.

  Recruiting Stanford University · Stanford, California · NCT05479474

• Evaluating a dietary supplement for improving sperm DNA quality

  This study is testing a dietary supplement to see if it can improve sperm DNA quality in men aged 20 to 45 who are struggling with infertility.

  Recruiting Gynov · Paris · NCT04959864

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Genetics of Male Infertility: Accelerating Discovery and Clinical Impact

  This grant aims to uncover the genetic causes of male infertility (azoospermia) to improve diagnosis and pave the way for personalized treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11400046

• Gut soy and male fertility: how the gut microbiome may affect testosterone and sperm health

  This grant explores how soy foods interact with the gut microbiome to influence male reproductive health, especially testosterone levels and sperm quality, in adults.

  NIH research Purdue University · West Lafayette, United States · NIH-11354651

• How heat harms sperm chromosome structures linked to male infertility

  This work looks at how warmer-than-normal temperatures change the protein structures that organize chromosomes during sperm production, which could help men with heat-related infertility.

  NIH research Colorado State University · Fort Collins, United States · NIH-11310215

• Understanding how temperature affects male fertility through chromosome structures

  This study looks at how heat affects sperm production in males, using tiny worms to understand why higher temperatures might lead to infertility and possibly increase cancer risk, helping us learn more about male reproductive health.

  NIH research Colorado State University · Fort Collins, United States · NIH-11290568

• Finding genes behind male infertility

  This project uses long-read DNA sequencing to find genes and mutations that may cause infertility in men.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11223320

• Genetic causes of male infertility and azoospermia

  This project aims to find gene changes that cause nonobstructive azoospermia in men to improve diagnosis and guide future treatments.

  NIH research Magee-Women's Res Inst and Foundation · Pittsburgh, UNITED STATES · NIH-11194422

• Exploring the link between genetic mutations and male infertility

  This study is looking at how higher rates of genetic changes in men might be linked to infertility and other health problems, and it involves men with varying fertility levels who will provide samples to help us understand these connections better.

  NIH research University of Utah · Salt Lake City, United States · NIH-11120851

• Understanding the genetics behind male infertility

  This study is looking at the genes that might cause male infertility, especially a condition called nonobstructive azoospermia, which affects about 1 in 100 men, to help create better tests and treatments for couples dealing with infertility.

  NIH research Magee-Women's Res Inst and Foundation · Pittsburgh, UNITED STATES · NIH-10992989

• Identifying new genes linked to male infertility

  This study is looking at the DNA of men who have trouble fathering children to find out if there are specific genes or changes in their genes that might be causing infertility, and it hopes to help improve how we diagnose these issues in the future.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10983775

Related topics

Quick answers

How many Male Infertility clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in Spain (4 trials), United States (2 trials), Taiwan (2 trials), France (1 trial), Egypt (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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