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Clinical trial Recruiting at 1 site Interventional Ages 40 and up

Live motile sperm sorting device vs standard sperm prep in older men for IVF outcomes

Official title: Evaluation of the Effectiveness of Live Motile Sperm Sorting Device on In Vitro Fertilization Outcomes in Advanced Paternal Age Group

Run by Vietnam Military Medical University · NCT07605182 · Data updated 2026-11-12

This study tests whether the LensHooke CA0, a centrifugation-free sperm sorting method, improves IVF outcomes for couples where the male partner is 40 or older.

Quick facts

Study typeInterventional
Ages40 Years and up
SexAll
Enrollment378 (estimated)
SponsorVietnam Military Medical University
Academic / other
Locations1 site (Hà Nội, Ha Dong)
StatusRecruiting
StartedJuly 15, 2026
Main results expectedApril 30, 2027
Study endsDecember 30, 2027
Registry record updatedAugust 20, 2026
Trial IDNCT07605182 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are couples where the male partner is 40 years or older, with adequate semen parameters and female partners with at least 5 mature oocytes undergoing ICSI with PGT-A and eSET.

Probably not a fit

Male partners younger than 40, or couples not using PGT-A/eSET, may not experience the same benefits.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In men aged 40 or older, sperm DNA fragmentation tends to be higher and conventional sperm preparation can add stress to sperm. This prospective comparative study compares LensHooke CA0 with traditional density gradient centrifugation for sperm processing in IVF/ICSI cycles using PGT-A and single embryo transfer. Outcomes include post-processing sperm quality, DNA fragmentation index, blastocyst formation, euploid embryo rate, and clinical pregnancy. The trial centers on couples undergoing ART at Vietnamese institutions with shared sponsorship. It aims to determine if a centrifugation-free approach can improve reproductive metrics in this population.

Why it matters

Potential benefit: If successful, LensHooke CA0 could improve IVF success rates and embryo quality for older male partners.

How similar studies have gone: Earlier research suggests that non-centrifugation sperm processing may reduce DNA damage, but results vary and further confirmation is needed.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Male partners aged ≥ 40 years
* Semen analysis: volume ≥ 1.4 mL, sperm concentration ≥ 6 million/mL, progressive motility (PR) ≥ 20% after 3-5 days of abstinence.
* Female partners with ≥ 5 mature (MII) oocytes retrieved.
* Couples undergoing ICSI with PGT-A and elective single embryo transfer (eSET).
* Willingness to participate and sign informed consent.

Exclusion Criteria:

* Azoospermia, surgical sperm retrieval, or use of cryopreserved sperm.
* Female uterine or ovarian conditions severely affecting IVF outcomes.
* Use of donor sperm or donor oocytes

Where it's running

  • Vietnam Military medical university
    Hà Nội, Ha Dong, Vietnam     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.