Evaluating a new method for sperm capacitation

Efficacy and Safety of a New Sperm Capacitation Method: a Prospective in Vitro Study on Semen Samples

Observational Fecundis Lab SL · NCT06742437

This study is testing a new method called HyperSperm to see if it can improve sperm quality for men who are having trouble with fertility.

Quick facts

Study typeObservational
Enrollment300 (estimated)
Ages18 Years to 60 Years
SexMale
SponsorFecundis Lab SL Academic / other
Locations4 sites (Barcelona, Barcelona and 3 other locations)
Trial IDNCT06742437 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess the efficacy and safety of a new sperm capacitation method called HyperSperm. It involves a prospective, multicenter design where 300 semen samples with various characteristics and abnormalities will be analyzed over a 12-month period. The study utilizes a split-sample approach, comparing standard sperm preparation with the new method without any intervention. The goal is to gather data on how well HyperSperm performs in improving sperm quality for men facing reproductive issues.

Who should consider this trial

Good fit: Ideal candidates for this study are men who can provide a semen sample and are experiencing male infertility or related sperm quality issues.

Not a fit: Patients currently diagnosed with sexually transmitted infections or those who have participated in a clinical trial involving an intervention within the last 3 months may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a new method to enhance sperm quality, potentially improving fertility outcomes for men with reproductive issues.

How similar studies have performed: While this approach is innovative, it is unclear if similar studies have shown success, as this specific method has not been widely tested.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Ability to provide a semen sample via masturbation

Exclusion Criteria:

* Current diagnosis of a sexually transmitted infection (STI)
* Previous diagnosis of hepatitis A, B, C, D, or HIV
* Prior participation in this study
* Participation in a clinical trial involving an intervention within the last 3 months

Where this trial is running

Barcelona, Barcelona and 3 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Reproductive IssuesMale InfertilityAsthenozoospermiaOligozoospermiaTeratozoospermia
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.