Correlation between PLC zeta measurements and semen parameters in male infertility

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study examines the relationship between phospholipase C zeta (PLCζ) measurements in semen and common semen parameters in men with infertility. Participants are couples pursuing IVF/ICSI or routine semen analysis, with leftover sperm available for testing. No intervention is administered beyond standard clinical care, and treatment outcomes from routine procedures are collected for analysis. The goal is to see if PLCζ levels could explain variability in fertilization potential and embryo development. The study is conducted at Fakih IVF Fertility Center in Abu Dhabi with collaboration from Khalifa University for Science and Technology.

Why it matters

Who can join: the full rules

Couple inclusion criteria:

* Presenting to the IVF clinic for IVF/ICSI treatment or routine semen analysis
* Semen sample must have a total sperm count of ≥1 million sperm/ml
* Availability of excess, leftover sperm after clinical treatment procedures
* Couples must have experienced infertility for at least one year and be undergoing fertility treatment
* Undergoing standard clinical treatment protocols (including embryo culture and, when applicable, PGTA) with routinely collected treatment outcome data
* Sufficient ovarian reserve and/or meeting the clinic's standard criteria for fertility treatment

Couple exclusion criteria:

* Known genetic disorders affecting fertility
* History of vasectomy or other irreversible sterilization procedures
* Current use of medications known to affect sperm parameters (e.g., exogenous androgens, chemotherapeutic agents, or other drugs specifically impacting spermatogenesis)
* Recent history of chemotherapy or radiation therapy
* Female age \>38 years old
* Known chromosomal abnormalities or genetic disorders that directly affect oocyte quality or embryo development
* Presence of severe uterine or pelvic pathology (e.g., significant uterine anomalies, advanced endometriosis)
* Documented ovarian failure or extremely diminished ovarian reserve as determined by AMH levels (AMH \>1 ng/mL, AFC ≥5)
* Use of medications or undergoing treatments that could significantly alter oocyte quality or embryogenesis (outside standard ART protocols).

Where it's running

• Fakih IVF
  Abu Dhabi, United Arab Emirates Recruiting
• Khalifa University
  Abu Dhabi, United Arab Emirates Active not recruiting

Study contacts

• Principal investigator: Junaid Kashir, PhD — Khalifa University
• Study coordinator: Dr. Lamiya Mohiyiddeen, MD, FRCOG
• Email: lamiya.mohiyiddeen@fakihivf.com
• Phone: +971543676002

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.