Royal Jelly to Help Unexplained Male Infertility
Official title: Effect of Oral Royal Jelly Supplementation on Sperm DNA Fragmentation Index and Pregnancy in Couples With Unexplained Infertility: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Study
Run by Medipol University · NCT07337265 · Data updated 2026-11-12
A randomized, placebo-controlled study tests whether daily royal jelly can improve sperm DNA integrity and help couples achieve pregnancy when the man’s fertility appears normal by standard tests.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Men only |
| Enrollment | 80 (estimated) |
| Sponsor | Medipol University Academic / other |
| Locations | 1 site (Istanbul, Başakşehir) |
| Status | Recruiting |
| Started | February 1, 2026 |
| Main results expected | December 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | August 19, 2026 |
| Trial ID | NCT07337265 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Men 18-45 with at least 1 year of infertility, normozoospermia by WHO 2021 criteria, and a partner with normal reproductive function.
✕Probably not a fit
Men with abnormal semen parameters or conditions excluding participation may not experience benefit and could have no change in pregnancy outcomes.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, double-blind trial compares 750 mg daily lyophilized royal jelly with a placebo for 90 days in men aged 18-45 with unexplained infertility and normozoospermia. The study focuses on sperm DNA fragmentation and oxidative stress markers, alongside tracking spontaneous pregnancy rates in couples. Participants must have a stable infertility history and normal female partner evaluations, with no prior antioxidant supplementation in the past three months. Outcomes will inform whether royal jelly’s antioxidant properties can protect DNA in sperm and potentially improve natural conception chances.
Why it matters
Potential benefit: If successful, royal jelly could offer a safe, non-pharmacologic option to improve sperm DNA integrity and natural pregnancy rates in this population.
How similar studies have gone: Prior studies show mixed effects of royal jelly on sperm parameters; this trial investigates a specific outcome—DNA integrity in normozoospermic men with unexplained infertility.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men aged 18-45 years. History of infertility for at least 1 year despite unprotected intercourse. Diagnosis of unexplained infertility with Normozoospermia according to WHO 2021 (6th Ed.) criteria: Concentration ≥ 16 million/mL Total Motility ≥ 42% Progressive Motility ≥ 30% Normal Morphology (Kruger) ≥ 4% Female partner with normal gynecological evaluation (regular ovulation, normal ovarian reserve, and proven tubal patency via HSG). Normal serum hormone levels (Testosterone, FSH, LH) Exclusion Criteria: * Any abnormality in spermiogram (Oligo-, Asteno-, or Teratozoospermia). Presence of clinical varicocele. Leukocytospermia (\>1 million/mL) or active infection. History of smoking (\>5 cigarettes/day) or BMI \> 30 kg/m². Use of any antioxidant supplementation within the last 3 months.
Where it's running
-
Istanbul Medipol University
Istanbul, Başakşehir, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Ali İhsan Memmi
- Email: alimemmi@gmail.com
- Phone: +90 537 922 0997
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.