Methylation markers from saliva to guide lung cancer screening

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The MET-SELS study investigates DNA methylation as a stable, biological indicator of smoking exposure to improve risk-based selection for lung cancer screening. Researchers analyze saliva from about 900 participants to see if epigenetic marks in AHRR and F2RL3 correlate with long-term tobacco exposure and lung cancer risk. Unlike brief nicotine measures, these methylation changes persist and may better identify high-risk individuals than traditional pack-year criteria. The study is led by Prof. Dr. Annemiek Snoeckx and conducted at UZA and the Centre for Medical Genetics, with partners at University Hospital Antwerp and Universiteit Antwerpen.

Why it matters

Who can join: the full rules

Cohort 1: Volunteers

Inclusion Criteria:

* Age: Must be \> 50 years of age
* Smoking History: Includes individuals with and without a smoking history

Cohort 2: ZORALCS-study participants

Inclusion Criteria:

* Age: 55-74 years old
* Smoking History: Includes individuals with a smoking history

Where it's running

• Antwerp University Hospital
  Antwerp, Antwerpen, Belgium Recruiting

Study contacts

• Principal investigator: Annemiek Snoeckx, MD, PhD — University Of Antwerp / Antwerp University Hospital
• Study coordinator: Charlotte Theuns
• Email: charlotte.theuns@uantwerpen.be
• Phone: +32470274088

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.