Lung cancer screening for people with unexplained weight loss

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate whether individuals experiencing unexplained weight loss are at a higher risk of having or developing lung cancer compared to those without such weight loss. Participants will undergo lung cancer screening using low-dose computed tomography (LDCT), which provides detailed images of the lungs with minimal radiation exposure. Additionally, blood samples will be collected to explore the potential of blood testing in diagnosing lung cancer. The study will include a screening questionnaire to gather relevant health information.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Eligible for American Cancer Society lung cancer screening, as follows as per the discretion of the screening team:

  * Age 50-80 years old
  * At least 20-pack year history of smoking
* Weight loss of 3-10%, defined as UWL, within any timeframe over the past in the 18 months prior to enrollment, that cannot be attributed to an underlying medical condition at the discretion of the enrolling investigator

  * Note that patients who have 3-10% weight may still be enrolled if the enrolling investigator does not conclude that the weight loss can be attributed to the patient's intentional efforts.
  * Documented weight loss can be self-reported or extracted from weights obtained during physician visits. However, if self-reported weight loss is contradicted by weight loss documented in the medical record (e.g. a patients states that (s)he lost 10 lbs in the past 6 months, but a weight documented in the medical record does not support that history), the measured and quantified weight change will be used to ascertain eligibility
* Life expectancy greater than 1 year, per assessment of the treating clinician.

Exclusion Criteria:

* Currently pregnant or trying to become pregnant via self-report
* Prior history of recent CT scan of the chest either through LDCT screening or with a scan of the chest (standard, not LDCT) performed within the past 12 months
* Prior history of NSCLC

  ○ Note that patients with a history of diagnosis of non-lung cancers are eligible for the study.
* Currently undergoing or referred for diagnostic evaluation due to clinical suspicion for malignancy (e.g., referred to a medical or surgical oncologist, or scheduled for biopsy on the basis of a suspicious imaging abnormality).
* Patients with a germline pathogenic genetic variant who have undergone whole body MRI within the past 12 months
* Unable to comply with study procedures

Where it's running

• Memorial Sloan Kettering at Basking Ridge (All Protocol Activities)
  Basking Ridge, New Jersey, United States Recruiting
• Memorial Sloan Kettering Monmouth (All Protocol Activities)
  Middletown, New Jersey, United States Recruiting
• Memorial Sloan Kettering Bergen (All Protocol Activities)
  Montvale, New Jersey, United States Recruiting
• Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities)
  Commack, New York, United States Recruiting
• Memorial Sloan Kettering Westchester (All Protocol Activities)
  Harrison, New York, United States Recruiting
• Memorial Sloan Kettering Cancer Center (All Protocol Activities)
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Alexis Chidi, MD, PhD — Memorial Sloan Kettering Cancer Center
• Study coordinator: Alexis Chidi, MD, PhD
• Email: chidia1@mskcc.org
• Phone: 212-639-8100

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Empowering patients to get lung cancer screening with support and navigation

  This pilot study tests a patient navigation and education program to see if it helps adults who are eligible start and complete low-dose CT lung cancer screening.

  Recruiting at 13 sites University of California, Irvine · Anaheim, California and 56 other locations · NCT07711691

• Quality Implementation of Lung Cancer Screening in Kentucky

  This project tests how well the QUILS system helps Kentucky lung cancer screening programs work together to screen at-risk residents more effectively.

  Recruiting at 17 sites University of Kentucky · Ashland, Kentucky and 16 other locations · NCT07682610

• Statewide Lung Cancer Screening Improvement in Nevada and Mississippi using the QUILS System

  This project tests whether a QUILS-based statewide initiative can expand and sustain high-quality lung cancer screening for people in Mississippi and Nevada.

  Recruiting at 13 sites University of Kentucky · Greenville, Mississippi and 12 other locations · NCT07682597

• Quality Improvement Implementation for Lung Cancer Screening (QUILS) Program Enhancement

  This project tests a quality improvement pathway in existing lung cancer screening programs to help identify and prioritize process changes that improve quality and patient retention.

  Recruiting at 17 sites University of Kentucky · Ashland, Kentucky and 16 other locations · NCT07639255

• Methylation markers from saliva to guide lung cancer screening

  This study tests whether DNA methylation patterns in saliva can more accurately identify people who should get a low-dose CT scan for lung cancer screening.

  Recruiting University Hospital, Antwerp · Antwerp, Antwerpen · NCT07631624

• Multilevel program to increase LDCT lung cancer screening and help African American smokers quit

  This program will try combining low-dose CT screening with culturally tailored smoking-cessation support to help African American smokers who are eligible for LDCT quit and get screened.

  Recruiting at 2 sites Louisiana State University Health Sciences Center in New Orleans · New Orleans, Louisiana and 1 other locations · NCT07576595

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.