Condition

Locally Advanced Pancreatic Adenocarcinoma clinical trials and research

• 16Clinical trials
• 3NIH research projects
• 8Countries

Newest Locally Advanced Pancreatic Adenocarcinoma clinical trials

All recruiting trials (16)

• AB801 with chemotherapy and immunotherapy for cholangiocarcinoma and pancreatic cancer

  This phase 1 study tests whether AB801 can be given safely with chemotherapy and immunotherapy in adults with border-line resectable, locally advanced, or metastatic cholangiocarcinoma or pancreatic cancer.

  Recruiting Phase 1 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT07619313

• Surgery after tumor-shrinking treatment for locally advanced pancreatic cancer

  This project will test whether doing surgery after at least four months of chemotherapy helps people with locally advanced pancreatic cancer that was initially considered not removable live longer and feel better.

  Recruiting Azienda Ospedaliera di Padova · Padova · NCT07241663

• XER-001 (nasoduodenal amifostine) with SBRT for locally advanced pancreatic cancer

  This trial tests whether giving XER-001 through a nasoduodenal tube together with stereotactic body radiotherapy (SBRT) is safe and helpful for people with locally advanced pancreatic cancer.

  Recruiting at 5 sites Phase 1/2 Xerient Pharma · Duarte, California and 4 other locations · NCT07157033

• Comparing NALIRIFOX to a modified gemcitabine/nab‑paclitaxel/cisplatin regimen for advanced pancreatic adenocarcinoma

  This compares NALIRIFOX to a modified gemcitabine/nab‑paclitaxel/cisplatin regimen to see if it helps people with untreated locally advanced or metastatic pancreatic ductal adenocarcinoma live longer or have better tumor responses.

  Recruiting at 2 sites Phase 2 Medical University of South Carolina · Charleston, South Carolina and 1 other locations · NCT07076212

• Adding panitumumab to chemotherapy for unresectable or metastatic KRAS wild-type pancreatic cancer

  This trial will test whether giving the antibody panitumumab along with standard chemotherapy helps people with unresectable, locally advanced, or metastatic KRAS wild-type pancreatic cancer live longer.

  Recruiting at 272 sites Phase 3 SWOG Cancer Research Network · Anchorage, Alaska and 273 other locations · NCT06998940

• Cell-based gene therapy for advanced pancreatic cancer after chemotherapy

  This study is testing a new cell-based gene therapy called RR001 to see if it can help people with advanced pancreatic cancer feel better after chemotherapy and possibly make them eligible for surgery.

  Recruiting Phase 1/2 EIR Biotherapies s.r.l. · Modena, Italy · NCT06861452

• Kinisoquin to prevent blood clots in people with advanced pancreatic cancer

  This trial will test whether Kinisoquin can prevent blood clots in people starting chemotherapy for metastatic or locally advanced pancreatic cancer.

  Recruiting at 3 sites Phase 3 Quercis Pharma AG · Ventura, California and 2 other locations · NCT06861088

• Adding acoustic cluster therapy to chemotherapy for locally advanced pancreatic cancer

  This trial will try adding Acoustic Cluster Therapy (PS101 plus ultrasound) to modified FOLFIRINOX chemotherapy for people with locally advanced pancreatic cancer who have not had prior treatment.

  Recruiting at 10 sites Phase 2 EXACT Therapeutics AS · Scottsdale, Arizona and 9 other locations · NCT06850623

• Comparing standard and prolonged chemotherapy before surgery for pancreatic cancer

  This study is testing whether giving longer chemotherapy before surgery can help people with tough-to-treat pancreatic cancer live longer and have better outcomes.

  Recruiting Phase 3 Sahlgrenska University Hospital · Gothenburg, VGR · NCT06714604

• PTM-101 treatment for pancreatic cancer

  This study is testing a new treatment called PTM-101 combined with chemotherapy to see if it can help people with certain types of pancreatic cancer who haven't had treatment before.

  Recruiting at 9 sites Phase 1 PanTher Therapeutics · Newport Beach, California and 8 other locations · NCT06673017

• High-dose radiation therapy for advanced pancreatic cancer after chemotherapy

  This study tests whether high-dose radiation therapy can help people with advanced pancreatic cancer who responded well to chemotherapy feel better and live longer.

  Recruiting at 2 sites Phase 2 University Health Network, Toronto · Toronto, Ontario and 1 other locations · NCT06453486

• Chemotherapy sequence for pancreatic cancer treatment

  This study is testing a new order of chemotherapy drugs to see if it helps people with hard-to-treat pancreatic cancer have their tumors completely removed through surgery.

  Recruiting at 2 sites Phase 2 Wake Forest University Health Sciences · Charlotte, North Carolina and 1 other locations · NCT05825066

• Combining radiation and tumor treating fields for advanced pancreatic cancer

  This study is testing if combining radiation therapy with a special device that delivers electric fields can help slow down tumor growth in people with advanced pancreatic cancer.

  Recruiting Baptist Health South Florida · Miami, Florida · NCT05679674

• Implementation program for advanced pancreatic cancer care

  This program is testing new ways to improve treatment and survival rates for people with locally advanced pancreatic cancer in the Netherlands by using the best practices from around the world.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT05524090

• Assessing survival and quality of life in patients with advanced pancreatic cancer

  This study looks at how long people with advanced pancreatic cancer live and how their quality of life is affected while being treated at different hospitals in the Nordic region.

  Recruiting Umeå University · Umeå · NCT05356039

• Sequential treatment for locally advanced pancreatic cancer

  This study is testing a new combination of chemotherapy treatments for people with locally advanced pancreatic cancer to see if it helps them live longer and better.

  Recruiting at 6 sites Phase 2 Institut du Cancer de Montpellier - Val d'Aurelle · Marseille, Bouches-du-Rhône and 8 other locations · NCT04570943

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Total Neoadjuvant Therapy for Borderline or Locally Advanced Pancreatic Cancer

  A multi-part treatment approach tests giving all chemotherapy and targeted radiotherapy before surgery to help patients with tough-to-remove pancreatic cancer become eligible for curative surgery.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11397470

• Intensive pre-surgery treatment for borderline and locally advanced pancreatic cancer

  This gives strong combination chemotherapy followed by high-dose targeted radiation before surgery for people with borderline resectable or locally advanced pancreatic cancer to shrink tumors and make surgery possible.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11169814

• New treatment approach for difficult-to-surgically-remove pancreatic cancer

  This study is looking at a new way to treat patients with tough-to-reach pancreatic cancer by giving them chemotherapy and radiation before surgery to help shrink the tumors and make surgery more successful.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10908415

Related topics

Quick answers

How many Locally Advanced Pancreatic Adenocarcinoma clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (9 trials), Italy (2 trials), Sweden (2 trials), Australia (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 3: 3, Phase 1: 2, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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