Condition

Neoadjuvant Chemotherapy clinical trials and research

• 13Clinical trials
• 10NIH research projects
• 6Countries

Newest Neoadjuvant Chemotherapy clinical trials

All recruiting trials (13)

• Tracking frailty and thinking before and after pre-surgery chemotherapy for advanced ovarian and endometrial cancer

  This study will see if an automated frailty score and brief thinking tests change after 3–4 cycles of neoadjuvant (pre-surgery) chemotherapy in people over 55 with advanced ovarian or endometrial cancer.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT07220512

• Seismocardiography to gauge fitness and predict outcomes before esophageal cancer surgery

  A noninvasive seismocardiography device is tested to see if it can quickly estimate a patient’s fitness and help predict surgical outcomes for adults with esophageal cancer who are planning curative treatment.

  Recruiting at 3 sites Guy's and St Thomas' NHS Foundation Trust · Guildford and 3 other locations · NCT07159711

• Sentinel lymph node biopsy after neoadjuvant chemotherapy for inflammatory breast cancer

  This trial will test whether sentinel lymph node biopsy after preoperative chemotherapy is feasible and safe for people with inflammatory breast cancer who initially had extensive lymph node involvement.

  Recruiting European Institute of Oncology · Milan · NCT07080944

• AI-guided ultrasound and MRI staging to guide bladder cancer treatment

  This project will test whether a deep-learning system using ultrasound, MRI, and pathology can more accurately stage bladder cancer and predict who will benefit from additional chemotherapy for patients with suspected bladder tumors.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07051083

• Megestrol acetate to prevent weight loss during preoperative chemotherapy for locally advanced colorectal cancer

  This trial tests whether taking megestrol acetate during mFOLFOX6 neoadjuvant chemotherapy can prevent weight loss and improve appetite in adults with locally advanced colorectal cancer.

  Recruiting Phase 3 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT06998758

• Comparing standard and prolonged chemotherapy before surgery for pancreatic cancer

  This study is testing whether giving longer chemotherapy before surgery can help people with tough-to-treat pancreatic cancer live longer and have better outcomes.

  Recruiting Phase 3 Sahlgrenska University Hospital · Gothenburg, VGR · NCT06714604

• Non-surgical treatment for breast cancer after chemotherapy

  This study tests if using radiotherapy alone is a safe and effective option for breast cancer patients who have responded well to chemotherapy, instead of undergoing surgery.

  Recruiting European Institute of Oncology · Candiolo, Turin and 1 other locations · NCT06281210

• Using advanced mammography techniques to assess breast cancer treatment response

  This study is testing two new mammography techniques to see if they can better predict how well chemotherapy is working for people with locally advanced breast cancer.

  Recruiting Early Phase 1 Stony Brook University · Stony Brook, New York · NCT06220214

• Using organoids to test chemotherapy sensitivity in breast cancer patients

  This study is testing if lab-grown mini tumors from breast cancer patients can help predict how well they will respond to chemotherapy before treatment starts.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06155305

• Comparing chemotherapy before and after surgery for pancreatic cancer

  This study is testing whether giving chemotherapy before surgery can help people with resectable pancreatic cancer do better and live longer, especially in Asian patients.

  Recruiting at 2 sites Phase 3 Seoul National University Hospital · Seoul and 1 other locations · NCT05529940

• Neoadjuvant chemotherapy followed by chemoradiation for advanced cervical cancer

  This study is testing if giving a special chemotherapy before standard radiation treatment can help people with advanced cervical cancer live longer and feel better.

  Recruiting Phase 3 Sun Yat-sen University · Guangzhou, Guangdone · NCT05367206

• Combining Camrelizumab with chemotherapy for left-sided obstructive colorectal cancer

  This study tests if combining a new immunotherapy drug with chemotherapy can help people with left-sided obstructive colorectal cancer live longer and have better surgery outcomes after getting a stent.

  Recruiting Beijing Chao Yang Hospital · Beijing, Beijing Municipality · NCT05202314

• Evaluating a new chemotherapy regimen for HER2-negative breast cancer before surgery

  This study is testing a new type of chemotherapy to see if it works better than standard treatment for women with HER2-negative breast cancer before they have surgery.

  Recruiting Phase 2/3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT04576143

NIH-funded research (10)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Magnetic resonance fingerprinting to gauge chemotherapy response in breast cancer

  A patient-facing look at using a special MRI method (MRF) to see early whether breast cancer is responding to preliminary chemotherapy.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11408782

• MRI-guided chemotherapy for borderline-resectable pancreatic cancer

  This project uses special MRI scans to help pick the best pre-surgery chemotherapy for people whose pancreatic tumor is touching nearby vessels but might be removable after treatment.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11385517

• 3D wearable NIR imaging to predict breast cancer response during treatment

  A noninvasive, portable 3D wearable optical test (NIRS tomography) will be used to spot early signs of how breast cancer is responding to chemotherapy, helping guide treatment for patients.

  NIH research Dartmouth College · Hanover, United States · NIH-11370652

• MRI fingerprinting to spot early breast tumor response to chemotherapy given before surgery

  This project uses a new MRI method to find early changes in breast tumors during chemotherapy given before surgery so doctors can change treatment sooner if needed.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11174436

• Improving how we track breast cancer chemotherapy with 3D imaging

  This project aims to develop a new 3D ultrasound method to see how well chemotherapy is working for breast cancer patients before surgery.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11160431

• New Wearable Imaging to See How Breast Cancer Responds to Chemotherapy

  This project is developing a new wearable imaging device to help doctors see very early if breast cancer treatment is working for patients receiving chemotherapy before surgery.

  NIH research Dartmouth College · Hanover, United States · NIH-11136328

• Using 3D wearable technology to predict breast cancer treatment outcomes

  This study is testing a new, easy-to-use imaging method that helps doctors see how well chemotherapy is working for breast cancer patients, so they can better understand how much cancer is left after treatment and improve chances for a healthier future.

  NIH research Dartmouth College · Hanover, United States · NIH-10939474

• How pre-surgery chemotherapy affects breast cancer spread

  This study is looking at how chemotherapy for breast cancer might sometimes help cancer cells spread to other parts of the body, and it aims to understand the role of certain immune cells in this process, which could lead to better treatment options for patients like you.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-10915646

• Using Magnetic Resonance Fingerprinting to Evaluate Breast Cancer Treatment Response

  This study is testing a new imaging method to help doctors see how well breast cancer patients are responding to their chemotherapy before surgery, so they can make better treatment decisions and improve results.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10894084

• Examining lymph node biopsy techniques after chemotherapy in advanced breast cancer patients

  This study is looking at whether a less invasive procedure called sentinel lymph node biopsy can help women with locally advanced breast cancer who have received chemotherapy, making it easier to check for cancer spread in the armpit without needing more complicated surgeries.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10656553

Related topics

Quick answers

How many Neoadjuvant Chemotherapy clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in China (6 trials), United States (2 trials), Italy (2 trials), United Kingdom (1 trial), South Korea (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 4, Early Phase 1: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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