Condition

Borderline Resectable Pancreatic Ductal Adenocarcinoma clinical trials and research

• 10Clinical trials
• 3Countries

Newest Borderline Resectable Pancreatic Ductal Adenocarcinoma clinical trials

All recruiting trials (10)

• SMAD4-tailored neoadjuvant therapy for pancreatic cancer that can be surgically removed

  This trial tests whether using SMAD4 mutation status can guide pre-surgery chemotherapy for patients with resectable or borderline resectable pancreatic ductal adenocarcinoma.

  Recruiting Phase 2 Northwestern University · Chicago, Illinois · NCT07748611

• DCE-MRI to help plan surgery for borderline resectable pancreatic cancer

  This trial tests whether adding DCE-MRI imaging to standard care can better gauge how pancreatic tumors respond to treatment in patients whose cancer might be removable by surgery.

  Recruiting Phase 1/2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT07705919

• Samuraciclib given before surgery or chemotherapy for certain pancreatic cancers

  This study tests whether taking samuraciclib before standard treatment is safe and helps patients with localized pancreatic cancer.

  Recruiting Phase 1 University of Washington · Seattle, Washington · NCT07645651

• AB801 with chemotherapy and immunotherapy for cholangiocarcinoma and pancreatic cancer

  This phase 1 study tests whether AB801 can be given safely with chemotherapy and immunotherapy in adults with border-line resectable, locally advanced, or metastatic cholangiocarcinoma or pancreatic cancer.

  Recruiting Phase 1 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT07619313

• PULSAR personalized ultrafractionated adaptive proton radiotherapy combined with systemic therapy for pancreatic cancer

  This trial will test whether personalized PULSAR proton radiotherapy given after initial chemotherapy can improve local control for people with borderline resectable, locally advanced, or limited metastatic pancreatic cancer.

  Recruiting Phase 2 Samsung Medical Center · Seoul, Select Province/State · NCT07269626

• Pre-surgery NALIRIFOX for borderline resectable pancreatic ductal adenocarcinoma

  This phase II study tries NALIRIFOX (liposomal irinotecan plus oxaliplatin, 5‑fluorouracil, and leucovorin) before and after surgery to see if it helps people with borderline resectable pancreatic ductal adenocarcinoma.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT06821997

• Exploring how diet and gut bacteria affect chemotherapy response in pancreatic cancer

  This study is testing how diet and gut bacteria affect how well people with pancreatic cancer respond to chemotherapy.

  Recruiting Emory University · Atlanta, Georgia · NCT06595160

• Tumor DNA and protein testing to understand pancreatic cancer treatment response

  This trial will test whether measuring tumor DNA and proteins from people with resectable or locally advanced pancreatic ductal adenocarcinoma can be done quickly enough and provide information about how their cancer responds to standard chemotherapy.

  Recruiting British Columbia Cancer Agency · Vancouver, British Columbia · NCT06574620

• Neoadjuvant chemotherapy for resectable pancreatic cancer

  This study is testing a combination of three chemotherapy drugs to see if it helps people with resectable pancreatic cancer get better before surgery.

  Recruiting Phase 2 Georgetown University · Washington D.C., District of Columbia and 1 other locations · NCT06423326

• Targeted therapy for pancreatic cancer using new drugs

  This study is testing new targeted therapies for pancreatic cancer to see how well they work and if they are safe for patients at different stages of the disease.

  Recruiting Early Phase 1 OHSU Knight Cancer Institute · Portland, Oregon · NCT04005690

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Quick answers

How many Borderline Resectable Pancreatic Ductal Adenocarcinoma clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (8 trials), Canada (1 trial), South Korea (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 2, Early Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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