Condition

Metastatic Pancreatic Cancer clinical trials and research

• 21Clinical trials
• 5NIH research projects
• 15Countries

Newest Metastatic Pancreatic Cancer clinical trials

All recruiting trials (21)

• First-line combo therapy with GnP, SHR-1701, and Apatinib for metastatic pancreatic cancer

  This trial tests whether adding SHR-1701 and Apatinib to standard GnP can safely and effectively treat previously untreated metastatic pancreatic cancer.

  Recruiting Phase 1/2 West China Hospital · Chengdu, Sichuan · NCT07802184

• Setidegrasib with mFOLFIRINOX or NALIRIFOX for KRAS G12D metastatic pancreatic cancer

  This trial tests whether adding setidegrasib to mFOLFIRINOX or NALIRIFOX helps people with metastatic pancreatic cancer who have a KRAS G12D mutation.

  Recruiting at 104 sites Phase 3 Astellas Pharma Inc · Gilbert, Arizona and 103 other locations · NCT07409272

• GFH375 plus chemotherapy in KRAS G12D-mutant metastatic pancreatic cancer

  This trial tests GFH375 in combination with standard chemotherapy to see if it helps people with KRAS G12D-mutant metastatic pancreatic cancer who have already been treated fail or progress on prior therapy.

  Recruiting Phase 3 Genfleet Therapeutics (Shanghai) Inc. · Beijing, Beijing Municipality · NCT07262567

• QL1706 plus chidamide with gemcitabine and nab-paclitaxel as first-line therapy for metastatic pancreatic cancer

  This study will test whether adding QL1706 and chidamide to standard gemcitabine plus nab‑paclitaxel helps people with newly diagnosed metastatic pancreatic adenocarcinoma.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin · NCT06951997

• Kinisoquin to prevent blood clots in people with advanced pancreatic cancer

  This trial will test whether Kinisoquin can prevent blood clots in people starting chemotherapy for metastatic or locally advanced pancreatic cancer.

  Recruiting at 3 sites Phase 3 Quercis Pharma AG · Ventura, California and 2 other locations · NCT06861088

• Miami EMPIRE: Eradication of Metastatic Pancreatic Cancer with Immuno-Radiation

  This trial will try adding targeted radiation to two immune checkpoint drugs, botensilimab and balstilimab, for adults with metastatic pancreatic ductal adenocarcinoma who progressed after at least one prior systemic therapy.

  Recruiting Phase 2 University of Miami · Miami, Florida · NCT06843551

• Combination treatment for advanced pancreatic cancer

  This study is testing a new combination treatment for advanced pancreatic cancer to see if it helps patients who haven't had treatment before.

  Recruiting Phase 1/2 Fujian Provincial Hospital · Fuzhou, Fujian and 3 other locations · NCT06761027

• Testing ERX-315 in patients with advanced solid tumors

  This study is testing a new treatment called ERX-315 to see if it is safe and effective for people with advanced solid tumors that haven't responded to other therapies.

  Recruiting at 5 sites Phase 1 EtiraRx Australia Pty Ltd · Ryde, New South Wales and 4 other locations · NCT06533332

• Treatment for advanced basal-like pancreatic cancer using a combination of drugs

  This study is testing a new combination of drugs to see if it can help people with advanced basal-like pancreatic cancer feel better when standard treatments aren't working.

  Recruiting Phase 1/2 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06483555

• Combination treatment for metastatic pancreatic cancer

  This study is testing a new combination of treatments for people with metastatic pancreatic cancer to see if it can help their immune system fight the cancer better.

  Recruiting Phase 1/2 Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT06454448

• Evaluating a new treatment combination for metastatic pancreatic cancer

  This study is testing a new combination of treatments for people with advanced pancreatic cancer to see if it works better than the standard care they usually receive.

  Recruiting at 52 sites Phase 2/3 Hutchmed · Hefei, Anhui and 51 other locations · NCT06361888

• Evaluating FOLFIRINOX treatment for advanced pancreatic cancer

  This study is testing if a specific chemotherapy called FOLFIRINOX can help people with advanced pancreatic cancer feel better and live longer compared to other treatments.

  Recruiting Phase 2 Centre Georges Francois Leclerc · Dijon · NCT05988814

• Low dose chemotherapy for metastatic pancreatic cancer

  This study is testing a low dose combination of chemotherapy drugs to see if it can help people with metastatic pancreatic cancer feel better and manage their disease.

  Recruiting Phase 2 National Cancer Centre, Singapore · Singapore · NCT05929885

• Using iodine-125 seeds and chemotherapy to treat metastatic pancreatic cancer

  This study is testing if combining radioactive iodine seeds with chemotherapy can help people with metastatic pancreatic cancer live longer compared to just chemotherapy alone.

  Recruiting Changhai Hospital · Shanghai, Shanghai Municipality · NCT05869474

• Evaluating liver embolization techniques for tumor management

  This study tests different liver embolization methods to see how well they help people with liver tumors live longer and maintain liver function while they continue their usual treatments.

  Recruiting IRCCS San Raffaele · Milan · NCT05714124

• Using alpha radiation emitters to treat advanced pancreatic cancer

  This study is testing a new type of radiation treatment for people with advanced pancreatic cancer to see if it can help shrink their tumors.

  Recruiting Alpha Tau Medical LTD. · Holon and 1 other locations · NCT05657743

• Molecular screening for advanced pancreatic cancer patients

  This study is testing if analyzing tumor and blood samples from patients with advanced pancreatic cancer can help doctors choose the best personalized treatment options before they start their first round of therapy.

  Recruiting Centre Leon Berard · Lyon · NCT05380414

• Liquid biopsy to detect AXL-positive circulating tumor cells in pancreatic cancer

  This test tries a blood-based liquid biopsy to see if AXL-positive circulating tumor cells can be found in adults with newly diagnosed metastatic pancreatic cancer who have not yet received treatment.

  Recruiting University Hospital, Montpellier · Montpellier · NCT05346536

• New drug metarrestin for treating metastatic solid tumors

  This study is testing a new drug called metarrestin to see if it can safely shrink tumors in adults and teens with advanced solid tumors that haven't responded to other treatments.

  Recruiting at 2 sites Phase 1 National Institutes of Health Clinical Center (CC) · Fairway, Kansas and 1 other locations · NCT04222413

• Treatment for metastatic cancer with BRCA or PALB2 mutations using chemotherapy and stem cells

  This study is testing a new treatment combining chemotherapy and stem cells for people with metastatic pancreatic or breast cancer who have BRCA or PALB2 mutations to see if it is safe and effective.

  Recruiting Phase 1 General Oncology, Inc. · Boston, Massachusetts and 1 other locations · NCT04150042

• Immunotherapy using tumor-infiltrating lymphocytes for metastatic cancer

  This study is testing a new immunotherapy that uses special white blood cells from patients' tumors to see if it can help people with metastatic cancers get better, especially when combined with another treatment called pembrolizumab.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01174121

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Predictive markers of response to Motixafortide, Cemiplimab, Gemcitabine and Nab-Paclitaxel in untreated metastatic pancreatic cancer

  This grant tests a combination therapy for people with newly diagnosed metastatic pancreatic cancer to see which patients respond best.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11391413

• Targeting barriers to treat metastatic pancreatic cancer

  Aims to combine local radiotherapy with a targeted immunotherapy delivered directly into pancreatic tumors to overcome treatment resistance and stop metastasis in patients with pancreatic cancer.

  NIH research University of Rochester · Rochester, United States · NIH-11381037

• Personalized multi‑antigen T‑cell therapy for metastatic pancreatic cancer after FOLFIRINOX

  Patients with metastatic pancreatic cancer who have completed FOLFIRINOX receive a personalized T‑cell treatment made from their own blood that targets several tumor proteins to help the immune system attack the cancer.

  NIH research Marker Therapeutics, INC. · Houston, United States · NIH-11180449

• Investigating the role of Engrailed-1 in metastatic pancreatic cancer

  This study is looking at how a protein called Engrailed-1 (EN1) affects the growth and spread of pancreatic cancer, with the hope of finding new ways to treat this tough disease.

  NIH research University of California at Davis · Davis, United States · NIH-11032047

• Using patient-derived T cells to target pancreatic cancer after chemotherapy

  This study is testing a new treatment called MT-601, which uses specially modified T cells from your own blood to help fight metastatic pancreatic cancer after you've had FOLFIRINOX chemotherapy, with the hope of improving how well your body can target and control the cancer.

  NIH research Marker Therapeutics, INC. · Houston, United States · NIH-11006021

Related topics

Quick answers

How many Metastatic Pancreatic Cancer clinical trials are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in China (8 trials), United States (7 trials), France (4 trials), Singapore (1 trial), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1/2: 4, Phase 3: 3, Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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