Condition

Locally Advanced clinical trials and research

• 18Clinical trials
• 27NIH research projects
• 12Countries

Newest Locally Advanced clinical trials

All recruiting trials (18)

• Dual PD1/CTLA4 immunotherapy with chemotherapy before surgery for locally advanced cervical cancer

  This study tests a combo of a PD1/CTLA4 bispecific antibody with standard chemotherapy to see if it can improve outcomes before surgery in women with locally advanced cervical cancer.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07646301

• AVZO-103 alone and with other treatments for advanced urothelial and other solid tumors

  This trial will test intravenous AVZO-103, alone and combined with other cancer drugs, to see if it is safe and helps adults with locally advanced or metastatic urothelial cancer or other solid tumors.

  Recruiting at 15 sites Phase 1/2 Avenzo Therapeutics, Inc. · San Francisco, California and 14 other locations · NCT07193511

• CUE-101 with pembrolizumab for locally advanced HPV‑16 positive oropharyngeal cancer

  This trial tests whether CUE-101 alone or combined with pembrolizumab before definitive therapy helps people with newly diagnosed, locally advanced HPV‑16 positive oropharyngeal cancer who are HLA‑A*02:01 positive.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT07172256

• YntraDose™ given before chemotherapy for locally advanced, unresectable pancreatic cancer

  This will test whether a one-time, image-guided injection of YntraDose™ (Y-90 radioactive microspheres) into the pancreatic tumor, combined with standard chemotherapy, is safe and can help control locally advanced unresectable pancreatic cancer.

  Recruiting at 2 sites BetaGlue Therapeutics SpA · Roma and 1 other locations · NCT07155850

• AVZO-1418 alone and with other treatments for advanced epithelial solid tumors

  This trial will test whether intravenous AVZO-1418, alone or with other cancer drugs, is safe and helps adults with locally advanced or metastatic epithelial solid tumors, including some lung cancers.

  Recruiting at 27 sites Phase 1/2 Avenzo Therapeutics, Inc. · Gilbert, Arizona and 26 other locations · NCT07038343

• Digital symptom monitoring for people starting cabozantinib plus nivolumab for advanced clear-cell kidney cancer

  This project tests whether weekly digital self-reports of symptoms can help guide treatment management for adults beginning cabozantinib plus nivolumab for advanced clear-cell kidney cancer during the first three months.

  Recruiting at 3 sites Phase 4 Centre Francois Baclesse · Annecy and 18 other locations · NCT07028125

• Combining chest radiation with PD‑1 and LAG‑3 immune blockers for locally advanced non-small cell lung cancer

  This trial tests whether three cycles of the immune drugs cemiplimab and fianlimab given before radiation — without initial chemotherapy — can shrink tumors on PET scans in people with locally advanced non-small cell lung cancer.

  Recruiting Phase 2 Montefiore Medical Center · The Bronx, New York · NCT06865339

• Investigating REC-1245 for advanced or metastatic cancer

  This study is testing a new oral medication called REC-1245 to see if it can help people with advanced or metastatic cancer who haven't responded well to standard treatments.

  Recruiting at 6 sites Phase 1/2 Recursion Pharmaceuticals Inc. · Duarte, California and 6 other locations · NCT06678659

• Lattice radiation therapy for treating large tumors

  This study is testing a new type of radiation therapy called lattice radiation therapy to see if it works better than standard treatment for people with large tumors.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT06416007

• Combining kidney-sparing surgery with postoperative radiotherapy for advanced ureteral cancer

  This study is testing if a new approach that combines kidney-sparing surgery with radiation after surgery can safely treat advanced ureteral cancer while keeping kidney function intact.

  Recruiting at 2 sites Peking University First Hospital · Beijing and 1 other locations · NCT06120387

• Accelerated immuno chemoradiotherapy for advanced lung cancer

  This study is testing a new fast treatment combining radiation and chemotherapy for people with advanced lung cancer to see if it works better than the usual approach.

  Recruiting at 10 sites Phase 2 TheraOp · Dresden and 10 other locations · NCT06102057

• Omitting radiation for advanced lung cancer patients who responded to treatment

  This study is testing whether skipping radiation for patients with advanced lung cancer who have responded well to initial treatment can help reduce side effects while still keeping the cancer under control.

  Recruiting Hubei Cancer Hospital · Wuhan, Hubei · NCT06020430

• Monitoring molecular residual disease in pancreatic cancer

  This study is testing if tracking tiny bits of cancer DNA in the blood can help doctors make better treatment decisions for people with pancreatic cancer that is hard to remove.

  Recruiting Peking Union Medical College Hospital · Beijing · NCT05802394

• Combining immunotherapy and chemotherapy for advanced lung cancer treatment

  This study is testing a new treatment that combines immunotherapy with chemotherapy to see if it can help people with advanced lung cancer turn their tumors into ones that can be surgically removed.

  Recruiting Phase 2 Shanghai Pulmonary Hospital, Shanghai, China · Shanghai · NCT05766800

• Target axillary dissection after chemotherapy for locally advanced breast cancer

  This study is testing if a new surgery method for removing lymph nodes after chemotherapy can help people with locally advanced breast cancer have better outcomes.

  Recruiting at 2 sites Hospital Universitari de Bellvitge · L'Hospitalet de Llobregat, Barcelona and 1 other locations · NCT05763641

• Combining radiation and tumor treating fields for advanced pancreatic cancer

  This study is testing if combining radiation therapy with a special device that delivers electric fields can help slow down tumor growth in people with advanced pancreatic cancer.

  Recruiting Baptist Health South Florida · Miami, Florida · NCT05679674

• Short-course radiotherapy followed by penpulimab plus CAPEOX before surgery for microsatellite-stable locally advanced rectal cancer

  This study tests whether short-course radiotherapy followed by the immunotherapy penpulimab combined with CAPEOX chemotherapy before surgery helps people with microsatellite-stable locally advanced rectal cancer.

  Recruiting Phase 2 Ruijin Hospital · Shanghai, None Selected · NCT05576480

• Evaluating PC14586 for advanced solid tumors with a specific mutation

  This study is testing a new oral medication called PC14586 to see if it can help people with advanced solid tumors that have a specific mutation in the TP53 gene.

  Recruiting at 71 sites Phase 1/2 PMV Pharmaceuticals, Inc · Irvine, California and 75 other locations · NCT04585750

NIH-funded research (27)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Globally useful predictor for cervical cancer treatment response

  This project aims to develop a simple predictive signature to personalize treatment for locally advanced cervical cancer using easy tests and imaging.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11622628

• Spatial control of immunogenic cancer killing for locally advanced lung cancer

  A new approach uses radiation-triggered nanoparticles to deliver cancer-killing drugs directly to lung tumors while sparing healthy tissue.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11428611

• Credentialing CDK 4/6 inhibitors with radiation to treat high-risk breast cancer

  A study from the University of Michigan aims to test whether adding CDK4/6 inhibitors to radiation therapy could improve outcomes for women with high-risk ER+ or triple-negative breast cancer.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11420513

• Targeted radiosensitization to improve local control in advanced cancers

  A Cancer research grant is exploring how combining radiation therapy with a targeted drug approach could better control locally advanced tumors.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11420492

• Total Neoadjuvant Therapy for Borderline or Locally Advanced Pancreatic Cancer

  A multi-part treatment approach tests giving all chemotherapy and targeted radiotherapy before surgery to help patients with tough-to-remove pancreatic cancer become eligible for curative surgery.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11397470

• Blood tests to predict who will respond to pre-surgery therapy for locally advanced rectal cancer

  A blood-based test is being developed to predict which patients with locally advanced rectal cancer will respond to neoadjuvant chemoradiation before surgery.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11330520

• Predicting who responds to preoperative therapy for rectal cancer using combined photoacoustic and ultrasound imaging

  A study is testing a new imaging method to better predict which locally advanced rectal cancer patients will respond to preoperative treatment so some may avoid unnecessary surgery.

  NIH research Washington University · Saint Louis, United States · NIH-11328818

• Dose levels of aerobic exercise during cancer therapy for rectal cancer

  A personalized exercise plan is tested to see how different amounts of aerobic training affect how well people with locally advanced rectal cancer tolerate their treatment.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11325432

• Light-activated drug delivery for locally advanced pancreatic cancer

  Using light-activated chemotherapy delivered directly inside pancreatic tumors to help people with locally advanced pancreatic cancer.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11320794

• Using a blood test that looks for tumor DNA to monitor early and locally advanced breast cancer

  This project uses a sensitive blood test that looks for tiny bits of tumor DNA to track treatment response in people with early or locally advanced breast cancer.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11306078

• Tucatinib and trastuzumab given before other treatments for HER2‑positive rectal cancer

  People with HER2‑positive locally advanced rectal cancer will receive tucatinib plus trastuzumab up front to shrink tumors and possibly avoid radiation or surgery.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11302663

• CDK4/6 drugs plus radiation for locally advanced ER-positive and triple-negative breast cancer

  This project tests whether adding CDK4/6 drugs to radiation helps women with locally advanced ER-positive or triple-negative breast cancer reduce the chance the cancer comes back.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11180419

• Targeted treatments to boost radiation for locally advanced cancers

  Looks at whether adding drugs that target cancer-specific weaknesses can make radiation more effective for people with locally advanced or inoperable tumors.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11180407

• Intensive pre-surgery treatment for borderline and locally advanced pancreatic cancer

  This gives strong combination chemotherapy followed by high-dose targeted radiation before surgery for people with borderline resectable or locally advanced pancreatic cancer to shrink tumors and make surgery possible.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11169814

• Identifying blood markers to predict treatment response in rectal cancer patients

  This study is looking at how a new blood test can help doctors figure out which patients with locally advanced rectal cancer will respond well to their treatment before they start, so they can tailor the therapy to each person and avoid unnecessary side effects.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11143949

• Monitoring breast cancer treatment using blood tests for tumor DNA

  This study is looking at how to better treat people with early and locally advanced breast cancer by checking for tiny bits of cancer DNA in their blood, which could help doctors spot any remaining cancer sooner and tailor treatments to each patient, reducing the chance of unnecessary therapies.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11136406

• Understanding how immunotherapy and radiation work together for cervical cancer

  This project aims to find better ways to predict which patients with advanced cervical cancer will respond best to a combination of immunotherapy and chemotherapy with radiation.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11133049

• Using light to enhance drug delivery for advanced pancreatic cancer treatment

  This study is testing a new way to treat locally advanced pancreatic cancer using light-activated liposomes to deliver chemotherapy directly to tumors, and it’s designed for patients looking for better treatment options that also help their immune system fight the cancer.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11091232

• Using advanced imaging to predict treatment response in rectal cancer

  This study is looking to help people with locally advanced rectal cancer by using new imaging methods to better understand how well they respond to treatment before surgery, which could help doctors make smarter choices and possibly spare some patients from unnecessary operations.

  NIH research Washington University · Saint Louis, United States · NIH-11088143

• Effects of aerobic training on cancer treatment tolerability in rectal cancer patients

  This study is looking at how different amounts of aerobic exercise can help people with locally advanced rectal cancer feel better and handle their treatment more easily, and it’s designed for patients who are about to start their cancer therapy.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11056086

• Targeted therapy for advanced rectal cancer with HER2 amplification

  This study is testing a new way to treat patients with a specific type of rectal cancer by using targeted medicines before the usual chemotherapy and surgery, hoping to shrink tumors and make treatment easier with fewer side effects.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11042258

• Using CDK 4/6 inhibitors with radiation to improve treatment for advanced breast cancer

  This study is looking at whether using CDK 4/6 inhibitors along with radiation therapy can help women with locally advanced estrogen receptor-positive or triple-negative breast cancer, especially those with more than three affected lymph nodes, by making the radiation treatment work better and reducing the chances of c

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10917032

• Improving radiation therapy for advanced cancers using targeted treatments

  This study is looking at ways to make radiation therapy work better for people with hard-to-treat cancers by pairing it with other treatments that target the cancer's specific features, and it aims to find out how to overcome challenges that make radiation less effective.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10917021

• New treatment approach for difficult-to-surgically-remove pancreatic cancer

  This study is looking at a new way to treat patients with tough-to-reach pancreatic cancer by giving them chemotherapy and radiation before surgery to help shrink the tumors and make surgery more successful.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10908415

• Combining a new drug with immunotherapy to treat advanced melanoma

  This study is exploring a new way to boost cancer treatment for people with advanced melanoma by using a special molecule called CBL0137 alongside two common immunotherapy drugs, nivolumab and ipilimumab, to help your immune system fight the cancer better.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-10867390

• Investigating factors that affect blood tests for early breast cancer detection

  This study is looking at how different ways of collecting and processing blood samples can help improve blood tests that check for early signs of breast cancer, and it's for patients with early or locally advanced breast cancer.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-10691211

• Examining lymph node biopsy techniques after chemotherapy in advanced breast cancer patients

  This study is looking at whether a less invasive procedure called sentinel lymph node biopsy can help women with locally advanced breast cancer who have received chemotherapy, making it easier to check for cancer spread in the armpit without needing more complicated surgeries.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10656553

Related topics

Quick answers

How many Locally Advanced clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (8 trials), China (7 trials), Germany (2 trials), Spain (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1/2: 4, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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