Condition

Stage IV Pancreatic Cancer AJCC v8 clinical trials and research

• 18Clinical trials
• 2Countries

Newest Stage IV Pancreatic Cancer AJCC v8 clinical trials

All recruiting trials (18)

• Understand cancer cachexia subtypes in advanced cancers

  This study tests how cancer cachexia presents in people with advanced colorectal, pancreatic, or lung cancer to see if different subtypes relate to outcomes.

  Recruiting Kaiser Permanente · Pleasanton, California · NCT07776353

• Combo therapy with selumetinib and trastuzumab deruxtecan for advanced pancreatic cancer

  This phase 1/2 trial tests whether the combination of selumetinib and DS-8201a (trastuzumab deruxtecan) is safe and whether it can help people with unresectable or metastatic pancreatic ductal adenocarcinoma.

  Recruiting Phase 1/2 National Cancer Institute (NCI) · Pittsburgh, Pennsylvania · NCT07619521

• AB801 with chemotherapy and immunotherapy for cholangiocarcinoma and pancreatic cancer

  This phase 1 study tests whether AB801 can be given safely with chemotherapy and immunotherapy in adults with border-line resectable, locally advanced, or metastatic cholangiocarcinoma or pancreatic cancer.

  Recruiting Phase 1 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT07619313

• BMS-986504 plus pemetrexed for MTAP-deleted metastatic solid tumors

  This study tests whether the combination of BMS-986504 and pemetrexed is safe and potentially effective for people with MTAP-deleted metastatic solid tumors.

  Recruiting Phase 1/2 Northwestern University · Chicago, Illinois · NCT07594626

• BMS-986340 with nivolumab plus gemcitabine and nab-paclitaxel for advanced or recurrent pancreatic adenocarcinoma

  This trial tests whether adding the antibody BMS-986340 to nivolumab together with gemcitabine and nab-paclitaxel helps people with metastatic or recurrent pancreatic adenocarcinoma.

  Recruiting at 3 sites Phase 2 Mayo Clinic · Scottsdale, Arizona and 2 other locations · NCT07226856

• Pegcetacoplan with modified FOLFIRINOX for metastatic pancreatic cancer

  This trial tests whether adding pegcetacoplan to modified FOLFIRINOX helps people with metastatic pancreatic ductal adenocarcinoma.

  Recruiting Phase 1/2 Roswell Park Cancer Institute · Buffalo, New York · NCT07214298

• TR-002 (Nadofaragene Firadenovec) given by IV for adults with advanced unresectable or metastatic solid tumors and refractory metastatic pancreatic adenocarcinoma

  This Phase 1 trial tests whether weekly intravenous TR-002 is safe and what dose is best for adults with advanced unresectable or metastatic solid tumors or refractory metastatic pancreatic cancer.

  Recruiting Phase 1 University of California, Davis · Sacramento, California · NCT07189195

• OMO-103 for advanced or metastatic pancreatic ductal adenocarcinoma

  This trial tests an experimental IV drug called OMO-103 to see if it changes tumor cells in adults with locally advanced or metastatic pancreatic ductal adenocarcinoma.

  Recruiting Early Phase 1 OHSU Knight Cancer Institute · Portland, Oregon · NCT07089940

• Adding panitumumab to chemotherapy for unresectable or metastatic KRAS wild-type pancreatic cancer

  This trial will test whether giving the antibody panitumumab along with standard chemotherapy helps people with unresectable, locally advanced, or metastatic KRAS wild-type pancreatic cancer live longer.

  Recruiting at 272 sites Phase 3 SWOG Cancer Research Network · Anchorage, Alaska and 273 other locations · NCT06998940

• Higher-dose targeted radiation for locally advanced pancreatic cancer

  This tests whether giving a higher, precisely targeted dose of radiation after initial chemotherapy helps people with locally advanced unresectable pancreatic cancer live longer.

  Recruiting at 327 sites Phase 3 NRG Oncology · Gilbert, Arizona and 332 other locations · NCT06958328

• Using pemigatinib to treat advanced pancreatic cancer with FGFR genetic changes

  This study is testing if a new drug called pemigatinib can help adults with advanced pancreatic cancer that has specific genetic changes feel better and possibly live longer.

  Recruiting at 109 sites Phase 2 Ohio State University Comprehensive Cancer Center · Birmingham, Alabama and 108 other locations · NCT06906562

• Observational study on cancer cachexia subtypes

  This study is trying to identify different types of weight and muscle loss in patients with advanced colorectal, lung, or pancreatic cancers to help improve future treatments.

  Recruiting at 196 sites University of Rochester · Fort Smith, Arkansas and 224 other locations · NCT06073431

• CPI-613 combined with hydroxychloroquine and chemotherapy for advanced solid tumors

  This study is testing a new combination of treatments, including CPI-613 and hydroxychloroquine, to see if it can help people with advanced solid tumors that haven't improved with other chemotherapy.

  Recruiting Phase 2 Northwestern University · Chicago, Illinois · NCT05733000

• Testing a combination of two anti-cancer drugs for HER2-positive solid tumors

  This study is testing a combination of two cancer drugs to see if they can safely help people with advanced HER2-positive solid tumors.

  Recruiting at 15 sites Phase 1 National Cancer Institute (NCI) · Duarte, California and 17 other locations · NCT05372614

• Testing a new drug combination for advanced cancer and lymphoma

  This study is testing a new combination of two drugs to see if it can help people with advanced cancer and lymphoma feel better and live longer.

  Recruiting at 3 sites Phase 1/2 National Cancer Institute (NCI) · New Haven, Connecticut and 2 other locations · NCT05053971

• Targeted therapy for pancreatic cancer using new drugs

  This study is testing new targeted therapies for pancreatic cancer to see how well they work and if they are safe for patients at different stages of the disease.

  Recruiting Early Phase 1 OHSU Knight Cancer Institute · Portland, Oregon · NCT04005690

• Real-time imaging of tumor blood vessels during surgery

  We will test whether a real-time microscope technique during surgery can show how well blood vessels in adults' solid tumors work and whether that helps predict if systemic cancer medicines can reach the tumor.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT03823144

• iExosomes for metastatic pancreatic cancer with KRAS G12D mutation

  This trial will test if iExosomes — tiny vesicles made from mesenchymal stromal cells that carry KRAS G12D-targeting siRNA — can help people with metastatic pancreatic ductal adenocarcinoma who have the KRAS G12D mutation.

  Recruiting Phase 1/2 M.D. Anderson Cancer Center · Houston, Texas · NCT03608631

Related topics

Quick answers

How many Stage IV Pancreatic Cancer AJCC v8 clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (18 trials), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 5, Phase 1: 3, Phase 2: 3, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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