Condition

Leiomyosarcoma clinical trials and research

• 19Clinical trials
• 8NIH research projects
• 17Countries

Newest Leiomyosarcoma clinical trials

All recruiting trials (19)

• REC-617 treatment in RB1-negative leiomyosarcoma for adults who have had prior therapy

  This study tests REC-617 to see if it can help control RB1-negative leiomyosarcoma in adults who have already received prior systemic treatment.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT07633756

• Methionine-Reduced Diet in Solid Tumors (early-phase)

  A small pilot study will test whether a methionine-reduced diet can change blood levels in adults with various solid tumors who are receiving standard cancer therapy.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT07628634

• Ivonescimab treatment for people with leiomyosarcoma

  We will try ivonescimab in adults with advanced or unresectable leiomyosarcoma to see if it controls the cancer and causes few or mild side effects.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07516925

• Three-week preoperative proton versus X-ray radiotherapy for localized soft tissue sarcoma

  This trial tests whether selecting proton rather than standard X‑ray radiotherapy before surgery for adults with localized soft tissue sarcoma can lower long-term radiation side effects without increasing surgical complications.

  Recruiting Phase 2 Oslo University Hospital · Bergen and 3 other locations · NCT07169344

• Combining STC-15 with Toripalimab for Advanced Cancers

  This study is testing whether combining a new cancer drug, STC-15, with toripalimab can help people with advanced cancers feel better and improve their treatment outcomes.

  Recruiting at 11 sites Phase 1/2 STORM Therapeutics LTD · San Francisco, California and 13 other locations · NCT06975293

• Exploring beliefs and attitudes about genetic testing in leiomyosarcoma patients

  This study looks at what leiomyosarcoma patients and their families think about genetic testing and how it might affect their understanding of cancer risk.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06875700

• Combining immune therapy with chemotherapy for advanced soft tissue sarcoma

  This study is testing if combining a new immune therapy with standard chemotherapy can help people with advanced soft tissue sarcoma who can’t have surgery or radiation feel better and live longer.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT06849986

• Investigating OKN4395 and Pembrolizumab for Solid Tumors

  This study is testing a new drug called OKN4395, alone and with another drug called pembrolizumab, to see if it can help people with solid tumors who have run out of other treatment options.

  Recruiting at 10 sites Phase 1 Epkin · Beverly Hills, California and 9 other locations · NCT06789172

• All-trans retinoic acid (ATRA) plus cemiplimab for advanced leiomyosarcoma

  This trial will try combining oral all-trans retinoic acid with the immunotherapy cemiplimab to see if it can shrink tumors or slow progression in adults with metastatic or unresectable leiomyosarcoma after standard chemotherapy.

  Recruiting Phase 2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT06528769

• MASCT-I plus doxorubicin and ifosfamide as first-line treatment for advanced soft tissue sarcoma

  This trial will test whether adding MASCT-I to standard chemotherapy (doxorubicin and ifosfamide) helps adults with advanced soft tissue sarcoma respond better or live longer.

  Recruiting Phase 2 HRYZ Biotech Co. · Guangzhou · NCT06277154

• Evaluating treatments for non-rhabdomyosarcoma soft tissue sarcoma in young patients

  This study is testing a combination of chemotherapy and radiation to see if it helps young patients with non-rhabdomyosarcoma soft tissue sarcoma live longer without their cancer coming back.

  Recruiting at 7 sites Phase 1/2 St. Jude Children's Research Hospital · Atlanta, Georgia and 6 other locations · NCT06239272

• Biomarker analysis for metastatic leiomyosarcoma patients

  This study is trying to see if blood and tissue samples can help find markers that show how well chemotherapy is working for patients with advanced leiomyosarcoma.

  Recruiting at 11 sites University of Michigan Rogel Cancer Center · Santa Monica, California and 10 other locations · NCT05653388

• Biomarker study for localized leiomyosarcoma

  This study is testing if a blood test for tumor DNA can help predict how well chemotherapy works for people with localized leiomyosarcoma who are at high risk of their cancer spreading after surgery.

  Recruiting at 3 sites University of Michigan Rogel Cancer Center · Ann Arbor, Michigan and 2 other locations · NCT04925089

• Using metronomic doses of trabectedin, gemcitabine, and dacarbazine for treating leiomyosarcoma

  This study is testing a new combination of three cancer drugs to see if they can help people with advanced leiomyosarcoma feel better and manage their disease.

  Recruiting Phase 2 Sarcoma Oncology Research Center, LLC · Santa Monica, California · NCT04535271

• Using Regorafenib to Maintain Treatment Benefits After Initial Therapy for Bone Sarcomas

  This study is testing if the drug regorafenib can help people with bone sarcomas stay cancer-free longer after their initial treatment.

  Recruiting at 12 sites Centre Leon Berard · Besançon and 15 other locations · NCT04055220

• Surgery with or without chemotherapy for high-risk retroperitoneal sarcoma

  This study is testing if giving chemotherapy before surgery can help people with high-risk retroperitoneal sarcoma live longer without their cancer coming back.

  Recruiting at 153 sites Phase 3 European Organisation for Research and Treatment of Cancer - EORTC · Birmingham, Alabama and 175 other locations · NCT04031677

• Phase 3 test of anlotinib (AL3818) versus dacarbazine in advanced alveolar soft part sarcoma, leiomyosarcoma, and synovial sarcoma

  This trial tests whether anlotinib (AL3818) helps adults with advanced alveolar soft part sarcoma, while earlier arms compared anlotinib to dacarbazine for leiomyosarcoma and synovial sarcoma that are no longer enrolling.

  Recruiting Phase 3 Advenchen Laboratories, LLC · Phoenix, Arizona and 23 other locations · NCT03016819

• Combining trabectedin with radiotherapy for treating soft tissue sarcoma

  This study is testing if combining a drug called trabectedin with radiotherapy can help people with different types of soft tissue sarcoma feel better and improve their treatment outcomes.

  Recruiting at 14 sites Phase 1/2 Grupo Espanol de Investigacion en Sarcomas · Bordeaux and 16 other locations · NCT02275286

• Registry for patients with rare diseases

  This study is creating a central registry for people with rare diseases to help connect them with researchers and improve treatments.

  Recruiting Sanford Health · Sioux Falls, South Dakota · NCT01793168

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Leiomyosarcoma treatment insights from tumor genetics

  A study looks at how tumor genetics relate to how leiomyosarcoma patients respond to standard systemic therapies.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11495322

• Genomic vulnerabilities in leiomyosarcoma: targeting DNA-PK pathways

  This grant aims to find targeted ways to treat leiomyosarcoma by exploiting the tumor’s DNA repair weaknesses and testing biomarkers that may guide therapy.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11419787

• Genetics and Genomics of Leiomyosarcoma: better understanding and new options for diagnosis and treatment

  A large research program is exploring the genetic drivers of leiomyosarcoma to help develop better ways to diagnose and treat this cancer.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11419778

• Targeting DNA repair weaknesses in leiomyosarcoma

  This project tests drugs that block a DNA-repair enzyme to make leiomyosarcoma tumors more sensitive to treatment for people with metastatic LMS.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11193258

• Understanding the genes behind leiomyosarcoma to improve diagnosis and treatment

  This project looks at how inherited and tumor gene changes, especially TP53 and other DNA repair genes, affect people with leiomyosarcoma to help create better tests and therapies.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11193247

• Developing a new mouse model for a rare type of uterine cancer

  This study is creating special mice that have a type of uterine cancer called leiomyosarcoma, so researchers can learn more about the disease and find better treatments for people who have it.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11010400

• Understanding genetic weaknesses in leiomyosarcoma

  This study is looking at leiomyosarcoma, a tough type of cancer, to understand how certain genetic changes can affect how it responds to treatment, with the goal of finding better ways to target and treat this cancer for patients like you.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10911936

• Understanding the genetics of leiomyosarcoma to improve diagnosis and treatment

  This study is looking at how certain gene changes might lead to leiomyosarcoma, a type of soft tissue cancer, and aims to find new ways to diagnose and treat it, with the hope of improving survival and quality of life for patients like you.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10911933

Related topics

Quick answers

How many Leiomyosarcoma clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (14 trials), China (3 trials), Italy (3 trials), Spain (3 trials), United Kingdom (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1/2: 3, Phase 3: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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