Condition

Liposarcoma clinical trials and research

• 16Clinical trials
• 6NIH research projects
• 19Countries

Newest Liposarcoma clinical trials

All recruiting trials (16)

• Personalised neoadjuvant therapy planning for adults with high‑risk soft tissue sarcoma

  This project tests whether analyzing tumor tissue and clinical data can help guide neoadjuvant chemotherapy decisions for adults with high‑risk soft tissue sarcomas.

  Recruiting Royal Marsden NHS Foundation Trust · London · NCT07432932

• Dose‑escalated, short‑course proton radiation for inoperable soft tissue sarcoma

  This will try higher-dose, shorter-course proton radiation to see if it controls tumors better in adults with inoperable soft tissue sarcoma.

  Recruiting Phase 2 Oslo University Hospital · Bergen and 1 other locations · NCT07173972

• Three-week preoperative proton versus X-ray radiotherapy for localized soft tissue sarcoma

  This trial tests whether selecting proton rather than standard X‑ray radiotherapy before surgery for adults with localized soft tissue sarcoma can lower long-term radiation side effects without increasing surgical complications.

  Recruiting Phase 2 Oslo University Hospital · Bergen and 3 other locations · NCT07169344

• GPC3-targeted CAR T cells armored with IL-15 and IL-21 for pediatric non‑CNS solid tumors

  This treatment will try personalized CAR T cells that target GPC3 and are engineered to make IL‑15 and IL‑21 in children and young adults with relapsed or refractory non‑CNS solid tumors that express GPC3.

  Recruiting Phase 1 Seattle Children's Hospital · Seattle, Washington · NCT07148050

• Testing mirdametinib with palbociclib for treating liposarcoma

  This study is testing a new combination of two medications, mirdametinib and palbociclib, to see if they can help people with advanced liposarcoma feel better and improve their treatment options.

  Recruiting at 7 sites Phase 1/2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06843967

• Using silmitasertib with chemotherapy for relapsed solid tumors

  This study is testing a new drug called silmitasertib combined with chemotherapy to see if it helps people with relapsed solid tumors feel better and manage their cancer.

  Recruiting at 24 sites Phase 1/2 Milton S. Hershey Medical Center · Birmingham, Alabama and 23 other locations · NCT06541262

• MASCT-I plus doxorubicin and ifosfamide as first-line treatment for advanced soft tissue sarcoma

  This trial will test whether adding MASCT-I to standard chemotherapy (doxorubicin and ifosfamide) helps adults with advanced soft tissue sarcoma respond better or live longer.

  Recruiting Phase 2 HRYZ Biotech Co. · Guangzhou · NCT06277154

• Evaluating treatments for non-rhabdomyosarcoma soft tissue sarcoma in young patients

  This study is testing a combination of chemotherapy and radiation to see if it helps young patients with non-rhabdomyosarcoma soft tissue sarcoma live longer without their cancer coming back.

  Recruiting at 7 sites Phase 1/2 St. Jude Children's Research Hospital · Atlanta, Georgia and 6 other locations · NCT06239272

• IL-15 and IL-21–armored GPC3-CAR T cell therapy for adults with GPC3-positive solid tumors

  This trial tests whether CAR T cells engineered to target GPC3 and fortified with IL-15 and IL-21 can treat adults with GPC3-positive liver and other solid tumors.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT06198296

• Using Abemaciclib and Radiation Therapy Before Surgery for High-Risk Retroperitoneal Sarcoma

  This study is testing if taking a medication called abemaciclib along with radiation therapy before surgery can help shrink tumors in patients with high-risk retroperitoneal sarcoma.

  Recruiting Phase 1 University of Washington · Seattle, Washington · NCT06025747

• Combining APG-115 with PD-1 inhibitor for advanced liposarcoma and solid tumors

  This study is testing if combining a new drug called APG-115 with a PD-1 inhibitor can safely help people with advanced liposarcoma and other solid tumors.

  Recruiting at 2 sites Phase 1/2 Ascentage Pharma Group Inc. · Guangzhou, Guangdong and 2 other locations · NCT04785196

• Using engineered T cells to treat pediatric solid tumors

  This study is testing a new treatment using specially modified immune cells to see if they can help children with certain types of solid tumors, like liver cancer and rhabdomyosarcoma, feel better.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT04715191

• Testing a new drug for advanced solid tumors

  This study is testing a new drug for people with advanced solid tumors, like breast or prostate cancer, to see how safe it is and how well it works on its own or with other treatments.

  Recruiting at 11 sites Phase 2 Pfizer · Los Angeles, California and 38 other locations · NCT04557449

• New blood test for diagnosing liposarcomas

  This study is testing a new blood test to see if it can help diagnose liposarcomas without the need for invasive biopsies.

  Recruiting Institut du Cancer de Montpellier - Val d'Aurelle · Montpellier · NCT04224064

• Surgery with or without chemotherapy for high-risk retroperitoneal sarcoma

  This study is testing if giving chemotherapy before surgery can help people with high-risk retroperitoneal sarcoma live longer without their cancer coming back.

  Recruiting at 153 sites Phase 3 European Organisation for Research and Treatment of Cancer - EORTC · Birmingham, Alabama and 175 other locations · NCT04031677

• Combining trabectedin with radiotherapy for treating soft tissue sarcoma

  This study is testing if combining a drug called trabectedin with radiotherapy can help people with different types of soft tissue sarcoma feel better and improve their treatment outcomes.

  Recruiting at 14 sites Phase 1/2 Grupo Espanol de Investigacion en Sarcomas · Bordeaux and 16 other locations · NCT02275286

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Dissecting how liposarcoma cells differentiate and interact with immune cells to find new therapies

  This grant explores how liposarcoma cancer cells differentiate and how immune cells in the tumor environment influence progression, with the aim of finding new treatment options for patients.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11451233

• Preclinical mouse models of liposarcoma for immuno-oncology applications

  A research grant is studying immune-related ways to understand and treat liposarcoma using a specially engineered mouse model that mimics human tumors.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11447343

• Improving CDK4/6 therapy for liposarcoma by understanding resistance

  This project tests a combination therapy to overcome resistance to CDK4/6 inhibitors in patients with dedifferentiated liposarcoma and aims to improve treatment results.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11348992

• Improving treatment for liposarcoma by understanding drug resistance

  This study is looking to help patients with dedifferentiated liposarcoma by finding better ways to use a cancer treatment called CDK4/6 inhibitors, especially for those who don’t respond well to it, by testing a combination of two drugs, palbociclib and mirdametinib, to see if it can improve their treatment results.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11228162

• Finding biomarkers to predict treatment benefits for a specific type of cancer

  This study is looking at a new treatment approach for people with a rare type of cancer called liposarcoma, by combining two medications to see if they can work better together, and it aims to find out which patients might benefit the most from this combination.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11086685

• Investigating the immune environment of liposarcoma using genetically modified mice

  This study is looking at how certain immune cells, called memory T cells, work in the environment of liposarcoma tumors to find new ways to improve treatment for patients with this type of cancer.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11078329

Related topics

Quick answers

How many Liposarcoma clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (9 trials), China (3 trials), United Kingdom (3 trials), France (3 trials), Norway (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 5, Phase 2: 4, Phase 1: 4, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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