Understanding the genetics of leiomyosarcoma to improve diagnosis and treatment
Official title: Genetics and Genomics of Leiomyosarcoma (LMS): Improved understanding of cancer biology and new approaches to diagnosis and treatment
Funded at University of Michigan at Ann Arbor · NIH-10911933 · Data updated 2026-11-12
This study is looking at how certain gene changes might lead to leiomyosarcoma, a type of soft tissue cancer, and aims to find new ways to diagnose and treat it, with the hope of improving survival and quality of life for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 16, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $2,094,748 |
| NIH project number | 5P50CA272170-03 |
| Project ID | NIH-10911933 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with leiomyosarcoma, particularly women, Black Americans, and older adults.
✕Less likely to help
Patients with other types of cancer or those not diagnosed with leiomyosarcoma may not benefit from this research.
What this research studies
This research focuses on leiomyosarcoma (LMS), a type of soft tissue cancer, by investigating the genetic mutations that contribute to its development. The team aims to understand how changes in specific genes, like TP53, affect the biology of LMS and explore new diagnostic and treatment approaches. By collaborating across multiple institutions, the research seeks to enhance the survival and quality of life for patients with this aggressive cancer. Patients may be involved in clinical studies that test innovative therapies based on these genetic insights.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and more effective treatments for leiomyosarcoma patients.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in other cancers, suggesting potential for success in this area as well.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Schuetze, Scott Michael — University of Michigan at Ann Arbor
- Study coordinator: Schuetze, Scott Michael
Related research
Other NIH-funded projects on the same topics.
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Leiomyosarcoma treatment insights from tumor genetics
A study looks at how tumor genetics relate to how leiomyosarcoma patients respond to standard systemic therapies.
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Genomic vulnerabilities in leiomyosarcoma: targeting DNA-PK pathways
This grant aims to find targeted ways to treat leiomyosarcoma by exploiting the tumor’s DNA repair weaknesses and testing biomarkers that may guide therapy.
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Genetics and Genomics of Leiomyosarcoma: better understanding and new options for diagnosis and treatment
A large research program is exploring the genetic drivers of leiomyosarcoma to help develop better ways to diagnose and treat this cancer.
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Targeting DNA repair weaknesses in leiomyosarcoma
This project tests drugs that block a DNA-repair enzyme to make leiomyosarcoma tumors more sensitive to treatment for people with metastatic LMS.
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Understanding the genes behind leiomyosarcoma to improve diagnosis and treatment
This project looks at how inherited and tumor gene changes, especially TP53 and other DNA repair genes, affect people with leiomyosarcoma to help create better tests and therapies.
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Developing a new mouse model for a rare type of uterine cancer
This study is creating special mice that have a type of uterine cancer called leiomyosarcoma, so researchers can learn more about the disease and find better treatments for people who have it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.