Understanding genetic weaknesses in leiomyosarcoma
PROJECT 1: Genomic Vulnerabilities in Leiomyosarcoma (LMS)
This study is looking at leiomyosarcoma, a tough type of cancer, to understand how certain genetic changes can affect how it responds to treatment, with the goal of finding better ways to target and treat this cancer for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10911936 on NIH RePORTER |
What this research studies
This research focuses on leiomyosarcoma (LMS), a challenging type of cancer that often spreads and is difficult to treat. The team is investigating the genetic vulnerabilities of LMS, particularly how certain genetic mutations affect the cancer's response to treatment. They aim to identify biomarkers that indicate how the cancer behaves and how it can be targeted more effectively. By studying the DNA damage response mechanisms in LMS, the researchers hope to develop new therapies that increase the effectiveness of existing treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with leiomyosarcoma, particularly those with metastatic disease.
Not a fit: Patients with other types of cancer or those who do not have leiomyosarcoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with leiomyosarcoma, improving their chances of recovery.
How similar studies have performed: Previous research has shown promise in targeting DNA damage response pathways in various cancers, suggesting that this approach could be beneficial for leiomyosarcoma as well.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Fletcher, Jonathan Alfred — University of Michigan at Ann Arbor
- Study coordinator: Fletcher, Jonathan Alfred
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.