Optimizing Immunosuppression and EBV-Seronegative Kidney Allocation to Reduce PTLD Risk

Who could benefit from this research

What this research studies

If you are a person receiving a kidney from an EBV-seropositive donor, this research aims to understand how different levels of immunosuppression affect the risk of PTLD and EBV infection. The study plans to work with eight large kidney transplant centers to collect and analyze data on immune-suppressing regimens, EBV infection dynamics, and waiting times. By pairing EBV-seronegative donors with EBV-seronegative recipients where possible, researchers want to see if this strategy improves outcomes without dramatically increasing wait times. The ultimate goal is to identify practical changes that could be adopted to make kidney transplantation safer for patients at risk of EBV-related complications.

Why it matters

Where this research is happening

• University of Pennsylvania
  Philadelphia, United States Active

Researchers

• Principal investigator: Potluri, Vishnu Sagar — University of Pennsylvania
• Study coordinator: Potluri, Vishnu Sagar

Related research

Other NIH-funded projects on the same topics.

• Finding the best ways to prevent cancer in kidney transplant patients from Epstein-Barr Virus.

  This study is looking at how different ways of lowering the immune system's activity can help kidney transplant patients who receive organs from donors with a virus called Epstein-Barr, and it hopes to find better ways to prevent complications after the transplant.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11107209

• Personalized immunosuppression for kidney transplant patients

  This study is working on a special tool to help find the best medication plan for people who have received a kidney transplant, aiming to reduce side effects and improve their overall health.

  NIH research New York University School of Medicine · New York, United States · NIH-11015002

• Microbial clues to diagnose and predict infections in kidney transplant patients

  A patient-focused project will look for microbial biomarkers in stool, blood, and urine to help doctors predict and diagnose infections in people who have had a kidney transplant.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11471530

• Immunological mechanisms behind treatment-resistant kidney transplant rejection

  This grant explores why certain kidney transplant rejections don’t respond to standard treatments and what immune cells in the graft are driving that resistance.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11449432

• Complement-Bound Exosomes and Kidney Transplant Immunity

  This project studies how kidney transplant injury and rejection happen after surgery and whether blocking certain immune pathways during organ preservation could improve transplant outcomes.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11442411

• Blood vessel signals predicting heart problems after kidney transplant

  This project studies blood markers and tissue patterns after kidney transplants to identify which patients are at highest risk of cardiovascular problems.

  NIH research Yale University · New Haven, United States · NIH-11441506

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.