Condition

Hypothyroidism clinical trials and research

• 19Clinical trials
• 7NIH research projects
• 1New in 30 days
• 12Countries

Newest Hypothyroidism clinical trials

All recruiting trials (19)

• High BMI and periodontitis in Thai adults under 60

  This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.

  Recruiting Mahidol University · Bangkok, Ratchathewi · NCT07880717

• North Star desiccated porcine thyroid tablets for primary hypothyroidism

  This phase 3, open-label study tests whether North Star desiccated porcine thyroid tablets can help people with primary hypothyroidism who are already taking a stable dose of LT4.

  Recruiting at 2 sites Phase 3 Neuvosyn Laboratories, LLC · Modesto, California and 24 other locations · NCT07747103

• Can a smart wristband help guide levothyroxine dosing after total thyroidectomy

  This study tests whether nighttime heart rate and rhythm data from a wearable can hint if levothyroxine dose is too high or too low before the usual blood tests.

  Recruiting Yeditepe University Hospital · Istanbul, Kadıköy · NCT07733375

• Internal organ and muscle health in hypothyroidism

  This study tests how hypothyroidism affects organ size and muscle strength in adults receiving routine care in Andijan, Uzbekistan.

  Recruiting Andijan State Medical Institute · Andijan · NCT07707830

• Recovery of hypothyroidism caused by immune checkpoint inhibitors after stopping treatment

  This trial will test whether adults who developed hypothyroidism while on immune checkpoint inhibitors can stop levothyroxine after those cancer drugs are stopped.

  Recruiting Seoul National University Bundang Hospital · Seongnam-si · NCT07421869

• Evaluating diagnostic and therapeutic strategies for thyroid conditions

  This study is testing different ways to diagnose and treat thyroid problems, like hypothyroidism and thyroid cancer, to see which methods work best for patients.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06779747

• Effects of Different Resistance Training on Quality of Life in Women with Hypothyroidism

  This study is testing whether different types of strength training can improve the quality of life for women aged 35 to 45 who have hypothyroidism.

  Recruiting Cairo University · Suez · NCT06757712

• New treatment options for hypothyroidism

  This study is testing a new combination of two thyroid medications to see if it can help people with hypothyroidism feel better.

  Recruiting Phase 2/3 UConn Health · Farmington, Connecticut · NCT06731764

• Reducing unnecessary thyroid hormone use in older adults

  This study is testing a new program to help doctors give less unnecessary thyroid hormone to older adults by providing them with better information and support.

  Recruiting at 3 sites University of Michigan · San Francisco, California and 2 other locations · NCT06629272

• Registry for patients with thyroid hormone resistance

  This study is collecting information from patients with thyroid hormone resistance to see how their specific gene mutations affect their health and improve diagnosis and treatment.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT06566066

• Optimizing Levothyroxine Dosage for Patients After Thyroid Surgery

  This study is testing a new tool that helps find the right dose of levothyroxine faster for people who have had their thyroid removed, to see if it improves their health and ability to work compared to regular care.

  Recruiting at 3 sites University Hospital of North Norway · Bergen and 2 other locations · NCT06455371

• Improving lab diagnostics for patients with hypothyroidism using levothyroxine

  This study is trying to see if current lab tests accurately show thyroid hormone levels in people with hypothyroidism who are taking levothyroxine.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT06083636

• Flexible dosing of levothyroxine in older adults

  This study is testing if older adults on thyroid medication feel better with a lower or higher target for their thyroid hormone levels over six months.

  Recruiting Phase 4 University of Pennsylvania · Philadelphia, Pennsylvania · NCT06073665

• Understanding health improvements after mini gastric bypass surgery

  This study looks at how mini gastric bypass surgery can improve health issues related to obesity, like diabetes and sleep apnea, by tracking changes in body weight and other health markers after the surgery.

  Recruiting All India Institute of Medical Sciences, Bhubaneswar · Bhubaneswar, Odisha · NCT06015620

• Evaluating thyroid function and structure in Klinefelter syndrome

  This study is testing how well the thyroid works and looks in people with Klinefelter syndrome compared to healthy individuals and those with a specific thyroid condition.

  Recruiting University of Roma La Sapienza · Roma · NCT05581147

• Preventing thyroid problems in children undergoing radiation therapy for cancer

  This study is testing if giving a thyroid medication to children with cancer who are getting radiation therapy can help prevent thyroid problems later on.

  Recruiting Phase 3 Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Milan · NCT05316922

• Assessing hypothyroidism in elderly patients after TAVI

  This study looks at how common hypothyroidism is in older patients after they have a heart valve replacement procedure and what factors might contribute to it.

  Recruiting Universitair Ziekenhuis Brussel · Brussels · NCT04831957

• Thyroid hormone supplementation for patients on hemodialysis

  This study is testing if a thyroid hormone pill can help people on hemodialysis with mild thyroid issues feel better and improve their heart health.

  Recruiting University of California, Irvine · Orange, California · NCT03977207

• Understanding thyroid function disorders

  This study looks at people with thyroid problems, like hyperthyroidism and hypothyroidism, to see how these conditions develop and what factors might be involved.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001159

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Discontinuing low-dose levothyroxine in older adults with subclinical hypothyroidism

  This study tests whether stopping low-dose levothyroxine in people 65 and older with subclinical hypothyroidism is safe and helps their well-being.

  NIH research Biomedical Research Fdn/central Arkansas · Little Rock, United States · NIH-11427473

• New approaches to treating hypothyroidism with LT4/LT3 therapy

  A clinical study aims to find safer, more effective LT4/LT3 treatment regimens for adults with hypothyroidism to improve symptoms and heart health.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11365817

• MPower Hub: a web program to help adults manage type 2 diabetes with glucose and activity data

  This project helps adults with type 2 diabetes use continuous glucose and activity tracker data alongside goal-setting tools to improve daily diabetes self-care.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11296941

• Better Ways to Treat Hypothyroidism

  This project looks for the best way to combine two thyroid hormones, LT4 and LT3, to help people with hypothyroidism feel better and reduce heart risks.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11158865

• Investigating the effectiveness of combined T4 and T3 therapy for hypothyroidism

  This study is looking into how a combination of two thyroid hormones, LT4 and LT3, might help people with hypothyroidism feel better, especially since some still have symptoms even while taking the usual treatment.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11075334

• Improving care for patients with hypothyroidism using real-world data

  This study is looking at how well people with hypothyroidism are treated over time and how their thyroid hormone levels affect heart health, so if you're living with this condition, your health data could help us find better ways to manage it!

  NIH research University of Chicago · Chicago, United States · NIH-11055175

• New treatments for hypothyroidism

  This study is looking at new ways to treat hypothyroidism by testing a combination of two thyroid hormones to see how they work together, and it's for people who want better options for managing their condition.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-10944695

Related topics

Quick answers

How many Hypothyroidism clinical trials are recruiting right now?

19, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (6 trials), Italy (3 trials), Netherlands (1 trial), India (1 trial), Uzbekistan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2/3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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