Condition

Graves Disease clinical trials and research

• 34Clinical trials
• 1NIH research projects
• 1New in 30 days
• 34Countries

Newest Graves Disease clinical trials

All recruiting trials (34)

• ETHY-001 safety and activity in Thyroid Eye Disease (TED)

  This study tests ETHY-001 versus placebo to see if it is safe, tolerable, and shows activity in people with thyroid eye disease.

  Recruiting at 2 sites Phase 1 Ethyreal Bio, Inc. · Orland Park, Illinois and 2 other locations · NCT07885605

• Early risk stratification of thyroid eye disease in newly diagnosed Graves' disease

  This study tests whether early eye-related signs, blood and tear biomarkers, or eye surface features can predict who with Graves’ disease will develop thyroid eye disease within a year.

  Recruiting University of Copenhagen · Herlev · NCT07812194

• Felzartamab for Graves’ Disease: See if it helps control thyroids and reduce need for ATDs

  This study tests felzartamab vs placebo in adults with Graves’ disease to see if it can normalize thyroid hormones and let people stop anti-thyroid drugs.

  Recruiting at 14 sites Phase 2 Biogen · Glendale, Arizona and 13 other locations · NCT07722546

• AI-based MRI and ultrasound for thyroid-related eye disease

  This study tests an AI model using orbital MRI and eye ultrasound to help diagnose activity and severity of thyroid-associated ophthalmopathy and predict its course in adults.

  Recruiting Shanghai Changzheng Hospital · Shanghai, Huangpu District · NCT07716397

• YB-101 for Graves' Disease: safety, dosing, and how it works

  This study tests YB-101 versus placebo in adults with Graves' disease to see if it is safe, tolerated, and whether it can help thyroid symptoms over about 40 weeks.

  Recruiting at 25 sites Phase 2 Yarrow Bioscience, Inc. · Gilbert, Arizona and 31 other locations · NCT07682896

• BHV-1300 for adults with Graves’ disease

  This study tests BHV-1300 versus placebo in adults whose Graves’ disease makes them hyperthyroid.

  Recruiting at 56 sites Phase 3 Biohaven Pharmaceuticals, Inc. · Tucson, Arizona and 55 other locations · NCT07661056

• Efgartigimod for Graves’ Disease in Adults

  This study tests whether giving efgartigimod under the skin helps thyroid function and is safe for adults with Graves’ disease.

  Recruiting at 51 sites Phase 3 argenx · Aalst, Oost-Vlass and 50 other locations · NCT07596849

• Efgartigimod for Graves' Disease in adults

  We are testing if efgartigimod given under the skin can help adults with Graves' disease by improving thyroid function and whether it is safe and tolerable.

  Recruiting at 35 sites Phase 3 argenx · Carlsbad, California and 34 other locations · NCT07570316

• Efgartigimod for Graves' Disease in adults

  We are testing if efgartigimod given under the skin can help adults with Graves' disease by improving thyroid function and whether it is safe and tolerable.

  Recruiting at 35 sites Phase 3 argenx · Carlsbad, California and 34 other locations · NCT07570316

• Links between inflammation, thyroid antibodies, and retinal changes in Graves disease

  This study will see if blood markers of inflammation and thyroid antibodies are linked to retinal measurements from OCT in adults with Graves disease and in healthy adults.

  Recruiting Elazıg Fethi Sekin Sehir Hastanesi · Elâzığ, Elaziğ · NCT07480720

• Telehealth Music Therapy for adults with autoimmune endocrine disease and depression

  This study tests whether eight weeks of telehealth music therapy can improve quality of life and mood symptoms in adults with autoimmune endocrine diseases and depression.

  Recruiting Appalachian State University · Boone, North Carolina · NCT07413874

• How changing thyroid hormone levels affects blood sugar, lipids, and energy use

  This trial will test whether raising or lowering thyroid hormones in people with newly diagnosed Graves' disease or thyroid cancer changes blood sugar, insulin, and lipid metabolism using oral glucose tolerance tests.

  Recruiting University of Ulm · Ulm, Baden-Wurttemberg · NCT07410637

• In vivo CAR-T treatment for refractory Graves' disease

  This trial will test HN2301, an in‑body CAR‑T therapy, to see if it can control thyroid autoimmunity in adults whose Graves' disease has not responded to standard antithyroid drugs.

  Recruiting Early Phase 1 Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07333677

• Single and multiple doses of MER511 in adults with Graves' disease.

  This trial will test whether single or repeated doses of MER511 are safe and well tolerated in adults aged 18–55 who have Graves' disease, with the drug given either into a vein or under the skin.

  Recruiting at 17 sites Phase 1 Merida Biosciences · Torrance, California and 16 other locations · NCT07305818

• GenSci098 for adults with Graves' disease

  This phase 1 trial will test single increasing subcutaneous doses of GenSci098 to see if they are safe and well tolerated in adults with Graves' disease.

  Recruiting Phase 1 Changchun GeneScience Pharmaceutical Co., Ltd. · Shenyang, Liaoning · NCT07286656

• Allogeneic dual CD19/BCMA CAR-T therapy for refractory Graves' disease

  This will test an off-the-shelf CAR-T treatment that targets CD19 and BCMA to see if it can produce lasting remission in people whose Graves' disease has not responded to standard medications.

  Recruiting Early Phase 1 Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07261345

• Allogeneic anti‑CD19 CAR‑T therapy for refractory Graves' disease

  This will try a single dose of donor‑derived anti‑CD19 CAR‑T cells to lower TSH‑receptor antibodies and control hyperthyroidism in people whose Graves' disease has not responded to standard treatments.

  Recruiting Early Phase 1 Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07129642

• Prevalence of hidden thyroid cancer in people with Graves' disease having a total thyroidectomy.

  This project will see how common incidental thyroid cancer is in adults with Graves' disease who are having their thyroid removed and which clinical features or nodules predict it.

  Recruiting Minia University · Minya, Minya Governorate · NCT07059507

• Thyroid artery embolisation to shrink large benign thyroid nodules

  This pilot will try thyroid artery embolisation — a minimally invasive catheter procedure — to shrink large non-cancerous thyroid nodules and relieve symptoms in adults who cannot or prefer not to have surgery.

  Recruiting Royal Berkshire NHS Foundation Trust · Reading · NCT07046546

• Follow-up of drug treatment for people with Graves' disease in China

  This follow-up will test how well methimazole works and who is likely to relapse among adults with new or returning Graves' disease.

  Recruiting First Hospital of China Medical University · Shenyang, Liaoning · NCT07040306

• IMVT-1402 as a treatment for adults with Graves' disease

  This trial tests whether IMVT-1402 can lower thyroid overactivity in adults with Graves' disease who remain hyperthyroid despite antithyroid drugs.

  Recruiting at 157 sites Phase 2 Immunovant Sciences GmbH · Tucson, Arizona and 162 other locations · NCT07018323

• AI tool to detect thyrotoxic state using wearables in Graves’ disease

  A wearable-based AI tool is tested to see if it can flag thyrotoxicosis in adults with Graves’ disease by comparing heart-rate data during sleep to thyroid tests.

  Recruiting Thyroscope INC. · San Francisco, California · NCT07017907

• Rilzabrutinib treatment for adults with Graves' disease

  This trial will test two doses of the oral drug rilzabrutinib in adults with Graves' disease, with or without Graves' orbitopathy, to see which dose better controls hyperthyroidism and is safe.

  Recruiting at 19 sites Phase 2 Sanofi · Buenos Aires and 23 other locations · NCT06984627

• Testing BHV-1300 for treating Graves' Disease

  This study is testing a new treatment called BHV-1300 to see if it can help people with Graves' Disease manage their symptoms and improve their condition.

  Recruiting at 18 sites Phase 1 Biohaven Pharmaceuticals, Inc. · South Gate, California and 17 other locations · NCT06980649

• Thyroid removal for Graves' disease or amiodarone-induced thyrotoxicosis

  The study will try to see if adults having their thyroid removed for Graves' disease or amiodarone-induced thyrotoxicosis have different complication rates depending on how active their thyroid is before or during surgery.

  Recruiting at 13 sites Kantonsspital Winterthur KSW · Aalst and 14 other locations · NCT06963203

• OptiThyDose for children with congenital hypothyroidism and Graves' disease

  This trial will test whether the OptiThyDose math model helps doctors choose the right thyroid medicine dose for newborns with congenital hypothyroidism and children with Graves' disease.

  Recruiting at 6 sites University Children's Hospital Basel · Yerevan and 6 other locations · NCT06864351

• Assessing IMVT-1402 for treating Graves' disease in adults

  This study is testing a new treatment called IMVT-1402 to see if it can help adults with Graves' disease who still have high thyroid levels despite taking other medications.

  Recruiting at 124 sites Phase 2 Immunovant Sciences GmbH · Phoenix, Arizona and 133 other locations · NCT06727604

• Improving care for patients with Graves' disease

  This study is testing if a new approach to care that involves patients more actively can help adults with Graves' disease feel less mentally tired and improve their overall health.

  Recruiting Vastra Gotaland Region · Gothenburg · NCT06309316

• Teprotumumab for treating thyroid eye disease and thyroid dysfunction

  This study is testing how well teprotumumab can help people with thyroid eye disease who have serious symptoms like bulging eyes, pain, and double vision.

  Recruiting Walter Reed National Military Medical Center · Bethesda, Maryland · NCT06275373

• Improving mental fatigue in patients with Graves' disease

  This study is testing if a special course to help with mental fatigue can improve symptoms and quality of life for people with Graves' disease.

  Recruiting Vastra Gotaland Region · Gothenburg · NCT06134219

• Exploring immune markers linked to mental fatigue in Graves' disease

  This study looks at whether certain immune markers are linked to ongoing mental fatigue in people with Graves' disease after their thyroid levels are back to normal.

  Recruiting Vastra Gotaland Region · Gothenburg · NCT06081439

• Evaluating treatment approaches for Graves' disease management

  This study is testing different ways to use methimazole to treat Graves' disease and see how well they work in preventing the condition from coming back after stopping the medication for two years.

  Recruiting Phase 4 The First Affiliated Hospital with Nanjing Medical University · Nanjing · NCT05461820

• Using corticosteroids before surgery for autoimmune thyroid disease

  This study tests if taking a short course of corticosteroids before thyroid surgery can help people with Graves' disease or Hashimoto's disease have a smoother operation.

  Recruiting at 3 sites Phase 4 Indiana University · Indianapolis, Indiana and 2 other locations · NCT05435547

• Understanding thyroid function disorders

  This study looks at people with thyroid problems, like hyperthyroidism and hypothyroidism, to see how these conditions develop and what factors might be involved.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001159

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• New treatment targeting autoimmune responses in Graves' disease

  This study is testing a new treatment for Graves' disease that uses specially designed immune cells to target and remove the harmful cells causing your symptoms, aiming to tackle the problem at its source instead of just easing the symptoms.

  NIH research Brigham Young University · Provo, United States · NIH-11115191

Related topics

Quick answers

How many Graves Disease clinical trials are recruiting right now?

34, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 34 countries. The most sites are in United States (15 trials), China (7 trials), United Kingdom (6 trials), Spain (6 trials), Georgia (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 3: 4, Phase 1: 4, Early Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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