Internal organ and muscle health in hypothyroidism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This hospital-based cross-sectional study will characterize organ morphometry and musculoskeletal status in adults with hypothyroidism. Participants will undergo standard clinical and anthropometric assessments, ultrasound exams of the liver, pancreas, and kidneys, handgrip strength testing, and physical performance tests (Five Times Sit-to-Stand and 4-meter gait speed). Thyroid function will be characterized by measuring TSH and FT4, alongside data on hypothyroidism duration and treatment. The goal is to understand multi-organ changes and physical function in this population, addressing gaps in Central Asian data where comprehensive, standardized assessments are limited.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18-59 years.
* Previously established diagnosis of hypothyroidism.
* Receiving routine outpatient or inpatient care at participating healthcare institutions.
* Ability to undergo ultrasonographic, anthropometric and functional assessments.
* Provision of written informed consent.

Exclusion Criteria:

* Pregnancy or lactation.
* History of thyroid malignancy.
* Acute infectious or inflammatory disease at the time of enrolment.
* Severe decompensated cardiovascular, hepatic or renal disease preventing study procedures.
* Neurological or musculoskeletal disorders that preclude functional testing.
* Refusal or inability to provide written informed consent.

Where it's running

• Andijan State Medical Institute
  Andijan, Uzbekistan Recruiting

Study contacts

• Study coordinator: Abdukhalim Kh. Abdurakhimov, PhD
• Email: abduhalim@adti.uz
• Phone: +998941010091

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.