Reducing unnecessary thyroid hormone use in older adults
Official title: Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing
Run by University of Michigan · NCT06629272 · Data updated 2026-11-12
This study is testing a new program to help doctors give less unnecessary thyroid hormone to older adults by providing them with better information and support.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 65 Years and up |
| Sex | All |
| Enrollment | 900 (estimated) |
| Sponsor | University of Michigan Academic / other |
| Locations | 3 sites (San Francisco, California and 2 other locations) |
| Status | Recruiting |
| Started | December 2, 2024 |
| Main results expected | September 30, 2027 |
| Study ends | August 31, 2028 |
| Registry record updated | September 4, 2026 |
| Trial ID | NCT06629272 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 65 and older who are currently on thyroid hormone therapy and have low serum TSH levels or are using thyroid hormone for inappropriate reasons.
✕Probably not a fit
Patients with thyroid cancer, secondary hypothyroidism, or those who have had a total thyroidectomy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study tests a new intervention called D-THIO, aimed at helping healthcare providers reduce overtreatment of thyroid hormone in older adults. It involves a multi-level approach that includes educational materials for patients and guidance for providers. The trial will take place at three sites and will assess the effectiveness of D-THIO compared to standard care in improving provider and patient knowledge, as well as reducing inappropriate thyroid hormone use. The study will also explore factors that affect the implementation of this deprescribing strategy in various healthcare settings.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risks associated with thyroid hormone overtreatment in older adults.
How similar studies have gone: Other studies have shown promise in deprescribing interventions, making this approach both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Patient Eligibility: Inclusion Criteria: 1. age 65 years and older 2. on thyroid hormone therapy and have a serum Thyroid-stimulating hormone (TSH) \<0.5 mIU/L or are on thyroid hormone therapy for an inappropriate indication 3. English speaking 4. without cognitive impairment Exclusion Criteria: 1\) Patients with a diagnosis of thyroid cancer, secondary hypothyroidism, history of total thyroidectomy or hospitalization in the past 3 months will be excluded. Provider eligibility: Inclusion: Primary care physicians, endocrinologists, geriatricians, and Advanced Practice Providers (APPs) who practice at University of Michigan, Henry Ford Health System or University of California San Fransico (UCSF) and who prescribe thyroid hormone for eligible patients identified above will be eligible for study participation. Exclusion: Providers who don't prescribe thyroid hormone.
Where it's running
-
University of California San Francisco
San Francisco, California, United States Recruiting -
University of Michigan
Ann Arbor, Michigan, United States Recruiting -
Henry Ford Health System
Detroit, Michigan, United States Recruiting
Study contacts
- Principal investigator: Maria Papaleontiou — University of Michigan
- Study coordinator: Brittany Gay
- Email: bbartol@umich.edu
- Phone: 734-763-8608
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.