Preventing thyroid problems in children undergoing radiation therapy for cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to reduce the incidence of hypothyroidism in pediatric cancer patients receiving radiation therapy by suppressing thyroid-stimulating hormone (TSH) levels. Participants will be randomly assigned to either a TSH suppression group, receiving L-thyroxine, or a control group without TSH suppression. The study will involve baseline thyroid assessments and careful monitoring of hormone levels throughout the treatment process. The goal is to maintain TSH levels below a specific threshold during radiation therapy to prevent long-term thyroid dysfunction.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Any patient with medulloblastoma, Hodgkin/non-Hodgkin Lymphoma before radiotherapy (RT) planning including thyroid parenchyma without previous primary or secondary hypothyroidism;
2. Written informed consent prior to any study-specific analysis and/or data collection.

Exclusion Criteria:

1. Any patient with medulloblastoma, Hodgkin/non-Hodgkin Lymphoma after radiotherapy including thyroid parenchyma;
2. Not signed consent.

Where it's running

• Fondazione IRCCS Istituto Nazionale dei Tumori
  Milan, Italy Recruiting

Study contacts

• Study coordinator: Maura Massimino, MD
• Email: maura.massimino@istitutotumori.mi.it
• Phone: +0390223902593

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.