Improving care for patients with hypothyroidism using real-world data
Official title: Redefining and Improving Hypothyroidism Care Using Real-World Data
Funded at University of Chicago · NIH-11055175 · Data updated 2026-11-12
This study is looking at how well people with hypothyroidism are treated over time and how their thyroid hormone levels affect heart health, so if you're living with this condition, your health data could help us find better ways to manage it!
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $172,003 |
| NIH project number | 1K23DK138262-01A1 |
| Project ID | NIH-11055175 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with hypothyroidism who are currently receiving treatment with levothyroxine.
✕Less likely to help
Patients who do not have hypothyroidism or those who are not receiving treatment for the condition may not benefit from this research.
What this research studies
This research investigates how well patients with hypothyroidism are managed over time, particularly focusing on the effectiveness of current treatments that adjust thyroid hormone levels. By analyzing real-world clinical data, the study aims to understand the long-term effects of uncontrolled thyroid-stimulating hormone (TSH) levels on cardiovascular health. The research will utilize advanced methods, including machine learning, to identify better strategies for managing hypothyroidism and improving patient outcomes. Patients may be asked to provide their health data to help in this analysis.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies for hypothyroidism, reducing symptoms and lowering the risk of cardiovascular issues for patients.
How similar studies have gone: Previous research has shown that using real-world data and machine learning can effectively improve management strategies in chronic diseases, suggesting a promising approach for this study.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Ettleson, Matthew — University of Chicago
- Study coordinator: Ettleson, Matthew
Related research
Other NIH-funded projects on the same topics.
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Discontinuing low-dose levothyroxine in older adults with subclinical hypothyroidism
This study tests whether stopping low-dose levothyroxine in people 65 and older with subclinical hypothyroidism is safe and helps their well-being.
-
New approaches to treating hypothyroidism with LT4/LT3 therapy
A clinical study aims to find safer, more effective LT4/LT3 treatment regimens for adults with hypothyroidism to improve symptoms and heart health.
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MPower Hub: a web program to help adults manage type 2 diabetes with glucose and activity data
This project helps adults with type 2 diabetes use continuous glucose and activity tracker data alongside goal-setting tools to improve daily diabetes self-care.
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Better Ways to Treat Hypothyroidism
This project looks for the best way to combine two thyroid hormones, LT4 and LT3, to help people with hypothyroidism feel better and reduce heart risks.
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Investigating the effectiveness of combined T4 and T3 therapy for hypothyroidism
This study is looking into how a combination of two thyroid hormones, LT4 and LT3, might help people with hypothyroidism feel better, especially since some still have symptoms even while taking the usual treatment.
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New treatments for hypothyroidism
This study is looking at new ways to treat hypothyroidism by testing a combination of two thyroid hormones to see how they work together, and it's for people who want better options for managing their condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.