Can a smart wristband help guide levothyroxine dosing after total thyroidectomy
Official title: Comparative Evaluation of the Effectiveness of Levothyroxine Replacement Therapy After Total Thyroidectomy Using Smart Wristband-Measured Nocturnal Heart Rate and Heart Rhythm Parameters Versus Thyroid Function Tests
Run by Yeditepe University Hospital · NCT07733375 · Data updated 2026-11-12
This study tests whether nighttime heart rate and rhythm data from a wearable can hint if levothyroxine dose is too high or too low before the usual blood tests.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Yeditepe University Hospital Academic / other |
| Locations | 1 site (Istanbul, Kadıköy) |
| Status | Recruiting |
| Started | July 22, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | February 1, 2027 |
| Registry record updated | September 25, 2026 |
| Trial ID | NCT07733375 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older undergoing total thyroidectomy and starting levothyroxine replacement who can wear the smart band and attend the 1‑month follow-up.
✕Probably not a fit
Patients whose thyroid function stabilizes quickly or who do not show detectable wearable changes may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study will use a Xiaomi Smart Band 10 to monitor nighttime heart rate and rhythm in adults after total thyroidectomy who start levothyroxine. The researchers will compare wearable-derived metrics with standard thyroid function tests (TSH and free T4) performed about 4–6 weeks after surgery. The goal is to see if wearable data can identify under- or over-replacement earlier than routine blood tests. Participants wear the device during the first postoperative month to collect continuous physiological data. The study is conducted at Yeditepe University Koşuyolu Hospital in Istanbul.
Why it matters
Potential benefit: If successful, wearables could provide earlier insight into whether thyroid hormone replacement is at the right level, potentially reducing symptoms and optimizing dosing.
How similar studies have gone: Wearable health monitoring has shown promise in reflecting physiological changes related to thyroid status in other settings, but this specific approach after thyroidectomy is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older. * Undergoing total thyroidectomy at the Department of General Surgery, Yeditepe University Faculty of Medicine Hospital. * Initiation of postoperative levothyroxine replacement therapy as part of routine clinical care. * Willing and able to attend the routine 1-month postoperative thyroid function test follow-up. * Willing and able to wear the Xiaomi Smart Band 10 throughout the study period. * Able to provide written informed consent. Exclusion Criteria: * History of cardiac arrhythmia. * Current use of beta-blockers or other antiarrhythmic medications that may affect heart rate. * History of heart failure or advanced cardiovascular disease. * Diagnosed sleep disorders that may interfere with nighttime heart rate measurements. * Pregnancy. * Inability or unwillingness to wear the Xiaomi Smart Band 10 as required. * Missing clinical or laboratory data required for outcome assessment. * Refusal to participate or withdrawal of informed consent.
Where it's running
-
Yeditepe University Koşuyolu Hospital
Istanbul, Kadıköy, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Banu Erkal, MD
- Email: banu.erkal@yeditepe.edu.tr
- Phone: +905319867061
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Understanding thyroid function disorders
This study looks at people with thyroid problems, like hyperthyroidism and hypothyroidism, to see how these conditions develop and what factors might be involved.
-
ETHY-001 safety and activity in Thyroid Eye Disease (TED)
This study tests ETHY-001 versus placebo to see if it is safe, tolerable, and shows activity in people with thyroid eye disease.
-
High BMI and periodontitis in Thai adults under 60
This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.
-
North Star desiccated porcine thyroid tablets for primary hypothyroidism
This phase 3, open-label study tests whether North Star desiccated porcine thyroid tablets can help people with primary hypothyroidism who are already taking a stable dose of LT4.
-
Internal organ and muscle health in hypothyroidism
This study tests how hypothyroidism affects organ size and muscle strength in adults receiving routine care in Andijan, Uzbekistan.
-
Recovery of hypothyroidism caused by immune checkpoint inhibitors after stopping treatment
This trial will test whether adults who developed hypothyroidism while on immune checkpoint inhibitors can stop levothyroxine after those cancer drugs are stopped.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.