Monitoring COVID-19 immune responses in patients with blood cancers
Official title: Immuno-Serological Assays for Monitoring COVID19 in Patients with Hematologic Malignancies
Funded at Yale University · NIH-11160167 · Data updated 2026-11-12
This study looks at how well COVID-19 vaccines work in people with blood cancers or autoimmune diseases compared to healthy individuals, using skin samples and blood tests to better understand their immune responses, which could lead to more personalized treatments and vaccines for those with these conditions.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 30, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $107,220 |
| NIH project number | 3U01CA260507-02S3 |
| Project ID | NIH-11160167 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with hematologic malignancies or autoimmune diseases who have received a COVID-19 vaccine.
✕Less likely to help
Patients without hematologic malignancies or autoimmune diseases may not benefit from this research.
What this research studies
This research investigates how the immune system responds to COVID-19 vaccines in patients with hematologic malignancies compared to healthy individuals. It utilizes advanced imaging techniques to analyze skin biopsy samples from both groups, focusing on the presence of the SARS-CoV-2 Spike protein and other immune markers. By correlating these findings with blood tests, the study aims to understand the unique immune responses in patients with blood disorders or autoimmune diseases. This could help tailor COVID-19 treatments and vaccinations for these vulnerable populations.
Why it matters
Potential benefit: If successful, this research could lead to improved COVID-19 vaccination strategies and treatments for patients with hematologic malignancies.
How similar studies have gone: Other research has shown promising results in understanding immune responses to vaccines in similar patient populations, indicating that this approach has potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Fan, Rong — Yale University
- Study coordinator: Fan, Rong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.