Abnormal CD56 expression in hematologic cancers
Official title: Resident Doctor at Clinical Pathology Department
Run by Assiut University · NCT04546945 · Data updated 2026-11-12
This project will test if CD56 is abnormally expressed across different blood cancers in newly diagnosed patients.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 38 (estimated) |
| Sponsor | Assiut University Academic / other |
| Drugs / interventions | radiation |
| Locations | 2 sites (Asyut and 1 other locations) |
| Status | Recruiting |
| Started | March 20, 2027 |
| Main results expected | June 30, 2027 |
| Study ends | December 30, 2027 |
| Registry record updated | March 18, 2026 |
| Trial ID | NCT04546945 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Newly diagnosed patients with any hematologic malignancy who can provide required clinical samples at the study site are ideal candidates.
✕Probably not a fit
People with non-malignant hematologic disorders or those who have already received treatment for their malignancy are unlikely to be eligible or to gain direct benefit from this observational work.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
CD56 (NCAM) is normally found on natural killer cells and some T cells but has been reported in multiple myeloma and linked to worse outcomes in AML. This observational study will measure CD56 expression patterns in newly diagnosed patients with a range of hematologic malignancies using clinical samples collected at Assiut University. The investigators aim to map which disease types and cell populations show ectopic CD56 and to relate expression patterns to clinical categories. Findings will be descriptive and hypothesis-generating rather than interventional.
Why it matters
Potential benefit: If successful, the work could identify CD56 as a diagnostic or prognostic marker that helps classify subtypes of blood cancers and guide future research.
How similar studies have gone: Prior reports have found CD56 expression in multiple myeloma and a meta-analysis linked CD56 overexpression with poorer prognosis in AML, but its expression across many other hematologic malignancies remains largely uncharacterized.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with hematologic malignancies. * Newly diagnosed Exclusion Criteria: * Patients with hematologic disorders other than hematologic malignancies.
Where it's running
-
Assiut university
Asyut, Egypt Recruiting -
Assiut University
Asyut, Egypt Completed
Study contacts
- Study coordinator: asmaa H mohamed, R.DR
- Email: a94asmaa@gmail.com
- Phone: +201024850070
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.