Using exercise to enhance immune cell therapies for blood cancers
Exercise as an Immune Adjuvant for Gamma Delta T-cell Therapies in Hematologic Malignancies
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-11076207
This study is looking at how exercise might help boost a special cancer treatment for patients with blood cancers like leukemia and lymphoma, especially those who have had a relapse after a stem cell transplant.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11076207 on ClinicalTrials.gov |
What this research studies
This research investigates how exercise can improve the effectiveness of gamma delta T-cell therapies for patients with hematologic malignancies, such as acute lymphoblastic leukemia and non-Hodgkin's lymphoma. The approach involves mobilizing immune cells through exercise or a specific drug, then enhancing their cancer-fighting abilities by equipping them with a chimeric antigen receptor (CAR). By understanding how physical activity influences these immune cells, the research aims to develop a more effective treatment option for patients who have relapsed after stem cell transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with hematologic malignancies, particularly those who have experienced a relapse after hematopoietic stem cell transplantation.
Not a fit: Patients with solid tumors or those who are not eligible for T-cell therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients with certain types of blood cancers, potentially improving survival rates and quality of life.
How similar studies have performed: While the use of exercise as an immune adjuvant is a novel approach, preliminary studies have shown promise in enhancing immune responses, suggesting potential for success.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIMPSON, RICHARD J — UNIVERSITY OF ARIZONA
- Study coordinator: SIMPSON, RICHARD J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.