Mayo Clinic radiotherapy outcomes registry and biobank
Mayo Clinic Radiotherapy Patient Outcomes Registry and Biobanking Study
This project collects blood and tissue from people with solid tumors or blood cancers treated with photon or proton radiotherapy at Mayo Clinic Rochester to see if biological markers link to side effects and outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 15000 (estimated) |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Drugs / interventions | Radiation |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT02457962 on ClinicalTrials.gov |
What this trial studies
This observational registry collects clinical data and biological specimens (for example blood and tissue) from patients with solid tumors or hematologic malignancies who receive photon or proton radiotherapy at Mayo Clinic in Rochester. Specimens and treatment details will be stored in a biobank and linked to clinical outcomes including acute and late toxicities, quality of life measures, local control, and survival. Patients treated with curative-intent radiation are eligible and no investigational interventions are given as part of participation. Researchers will use the linked samples and data to search for biomarkers or patterns that might predict side effects or treatment effectiveness.
Who should consider this trial
Good fit: Patients with solid tumors or blood cancers receiving curative-intent photon or proton radiotherapy at Mayo Clinic Rochester are ideal candidates.
Not a fit: Patients treated with palliative radiation, those receiving care elsewhere, or patients who cannot provide samples or follow-up data are unlikely to benefit from this registry.
Why it matters
Potential benefit: If successful, it could help doctors predict which patients are most likely to benefit from or be harmed by specific radiotherapy approaches and enable more personalized treatment plans.
How similar studies have performed: Other institutional radiotherapy biobanks and registries have produced promising biomarker leads linking biological signatures to toxicity and outcomes, but validation across centers remains limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Treated with photon/proton at Mayo Clinic Rochester in Radiation Oncology 2. Radiation therapy for curative intent Exclusion Criteria: None
Where this trial is running
Rochester, Minnesota
- Mayo Clinic — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Nadia N. Laack, MD — Mayo Clinic
- Study coordinator: Clinical Trials Referral Office
- Email: mayocliniccancerstudies@mayo.edu
- Phone: 855-776-0015
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.