Identifying heart failure with preserved ejection fraction in Denmark
CoPenhagen Heart Failure With Preserved Ejection Fraction (CPH-HFpEF)
This study is trying to find and screen older adults in Denmark who are at risk for heart failure with preserved ejection fraction to better understand how to identify this condition and help those who might be affected.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 5000 (estimated) |
| Ages | 50 Years to 89 Years |
| Sex | All |
| Sponsor | Herlev and Gentofte Hospital Academic / other |
| Locations | 1 site (Hellerup) |
| Trial ID | NCT06685237 on ClinicalTrials.gov |
What this trial studies
This observational cohort study aims to identify and screen individuals at risk for heart failure with preserved ejection fraction (HFpEF) using data from the Danish National Health Registries. The study will recruit up to 5000 participants aged 50 and older from the Capital Region of Denmark who have at least two risk factors for HFpEF. Recruitment will be conducted through secure electronic communication to ensure privacy and efficiency. The study seeks to evaluate the effectiveness of identification and screening procedures for HFpEF and to understand barriers to participation among vulnerable populations.
Who should consider this trial
Good fit: Ideal candidates for this study are Danish adults aged 50 years and older with at least two risk factors for HFpEF.
Not a fit: Patients who are younger than 50 years, have prevalent heart failure, or have significant comorbidities such as dementia or cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early identification and management of heart failure with preserved ejection fraction, potentially reducing morbidity and mortality rates.
How similar studies have performed: Other studies have shown success in identifying and managing heart failure with preserved ejection fraction, but this specific approach is novel in the Danish context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Residence in the Capital Region of Denmark 2. Age ≥ 50 years 3. At least two risk factors for HFpEF defined as any of the following (for age ≥ 60 years, only one): * Hypertension * Diabetes mellitus * Chronic kidney disease * Atrial fibrillation * BMI \> 25 kg/m2 * Previous heart valve surgery * Ischemic heart disease * Obstructive sleep apnea * Furosemide 40 mg Exclusion Criteria: 1. Age ≥ 90 years 2. Prevalent HF 3. Dementia 4. Nursing home 5. Amyloidosis 6. Hemodialysis 7. Cancer diagnosed within the past 5 years (skin cancer not included) 8. Prior solid organ transplantation 9. Lung disease defined as any of the following: * World Health Organization Group 1 pulmonary hypertension * Chronic pulmonary embolism * Lung fibrosis * Chronic obstructive pulmonary disease (COPD) * Home oxygen
Where this trial is running
Hellerup
- Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte Hospital — Hellerup, Denmark (Recruiting)
Study contacts
- Study coordinator: Camilla I Ottosen, MD
- Email: camilla.ikast.ottosen@regionh.dk
- Phone: +4538674143
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.