Understanding heart failure with preserved ejection fraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on heart failure with preserved ejection fraction (HFpEF), a condition where the heart can pump blood normally but still causes symptoms like breathlessness and fatigue. It aims to uncover the underlying causes of HFpEF, improve diagnostic tests, and explore new treatment options. By creating a registry that collects detailed patient data over time, the study seeks to better understand the diverse mechanisms of HFpEF and enhance personalized treatment approaches. The collaboration among multiple centers will allow for extensive data analysis and machine learning applications to refine HFpEF classification.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Written informed consent
2. Diagnosis of HFpEF by a cardiologist with HF expertise, or a primary care physician with HF expertise, or a heart failure nurse
3. Natriuretic peptide levels measured

Exclusion Criteria:

1. LV EF \< 40% (at screening or any previous measurement)
2. Known infiltrative cardiomyopathy (e.g., amyloid, sarcoid, lymphoma, endomyocardial fibrosis)
3. Known active myocarditis, constrictive pericarditis, or cardiac tamponade
4. Known genetic hypertrophic cardiomyopathy or obstructive hypertrophic cardiomyopathy
5. Known arrhythmogenic right ventricular cardiomyopathy
6. Known severe primary valvular heart disease
7. Known idiopathic, heritable or drug-induced pulmonary arterial hypertension
8. Heart transplantation or ventricular assist device
9. Complex congenital heart disease

Where it's running

• Cwm Taf Morgannwg University Health Board
  Abercynon, United Kingdom Recruiting
• Buckinghamshire Healthcare NHS Trust
  Aylesbury, United Kingdom Recruiting
• University Hospitals Birmingham NHS Foundation Trust
  Birmingham, United Kingdom Recruiting
• Broomfield Hospital
  Chelmsford, United Kingdom Recruiting
• NHS Tayside
  Dundee, United Kingdom Recruiting
• Glasgow Royal Infirmary
  Glasgow, United Kingdom Recruiting

Study contacts

• Study coordinator: Fardad Soltani, MBChB MRCP
• Email: fardad.soltani@mft.nhs.uk
• Phone: 0161 291 3223

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Renal Nerve Stimulation to Help Blood Pressure in AF and HFpEF

  This study tests whether stimulating the kidneys with a catheter can safely lower blood pressure in adults with atrial fibrillation and HFpEF who also have hypertension.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT07893821

• Cardio-Metabolic Clinic care for adults with type 2 diabetes and cardiovascular disease

  This trial tests whether a specialized Cardio-Metabolic Clinic can improve heart function and overall health for adults with type 2 diabetes and cardiovascular disease compared with usual care.

  Recruiting Odense University Hospital · Svendborg · NCT07878325

• Optimised Cardio-Renal Care for CKD and heart disease

  This study tests whether a specialised Cardio-Renal Clinic can improve heart and kidney health and quality of life for adults with chronic kidney disease and cardiovascular disease.

  Recruiting Odense University Hospital · Svendborg · NCT07835828

• Resmetirom for MASH with HFpEF in adults

  This study tests whether resmetirom can be given safely and show liver-related effects in adults with MASH and heart failure with preserved ejection fraction over 24 weeks.

  Recruiting at 5 sites Phase 1 Madrigal Pharmaceuticals, Inc. · Peoria, Arizona and 4 other locations · NCT07830758

• Elecoglipron vs placebo for adults with HFpEF or HFmrEF

  This Phase 3 study tests whether elecoglipron helps people with HFpEF or HFmrEF who are on dapagliflozin and standard care.

  Recruiting at 24 sites Phase 3 AstraZeneca · Fairhope, Alabama and 678 other locations · NCT07761117

• Iron infusion and MRI to study inflammation in HFpEF

  A small early-phase study tests whether an iron infusion affects heart inflammation in people with HFpEF, using MRI measures before and after treatment.

  Recruiting Early Phase 1 University of Florida · Gainesville, Florida · NCT07634640

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.