LIFU for Chronic Pain and Generalized Anxiety Disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-arm, open-label case study with two cohorts (chronic pain and generalized anxiety disorder) and a 6-month follow-up to explore an accelerated LIFU neuromodulation protocol. The study uses low intensity focused ultrasound as the intervention to see if it can modulate symptoms. Participants must have moderate to severe pain for at least 3 months or meet validated criteria for GAD. The project is conducted at the Fralin Biomedical Research Institute in Roanoke, VA, led by Virginia Tech, with no stated collaborators. Outcome data will inform feasibility and signal of clinical effect, guiding future research.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* GAD Symptoms - GAD-7 score \>= 10, OASIS score \>= 8, or PSWQ score \>= 45. OR Chronic pain symptoms - moderate to severe pain, present for at least 3 months.

Exclusion Criteria:

* Claustrophobia
* Contraindications to MRI or CT
* Active medical disorder with CNS effects
* History of neurologic disorder
* History of head injury with LOC \> 10 minutes
* Active drug or alcohol dependence

Where it's running

• Fralin Biomedical Research Institute at VTC
  Roanoke, Virginia, United States Recruiting

Study contacts

• Study coordinator: Jessica Research Associate, MPH
• Email: jnw@vtc.vt.edu
• Phone: 540-526-2261

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.