Understanding how gastrointestinal cancers start and progress
Official title: Translational Science of Gastrointestinal Cancer Initiation and Progression
Funded at Fred Hutchinson Cancer Center · NIH-10913595 · Data updated 2026-11-12
This study is looking into how certain changes in the body can lead to gastrointestinal cancers like colorectal and esophageal cancer, with the goal of finding better ways to prevent and catch these cancers early, which could help patients get better treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 19, 2018 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $345,951 |
| NIH project number | 5R50CA233042-08 |
| Project ID | NIH-10913595 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at high risk for colorectal cancer or esophageal adenocarcinoma, particularly those with precancerous lesions.
✕Less likely to help
Patients with no history of gastrointestinal issues or those who do not have risk factors for these cancers may not benefit from this research.
What this research studies
This research investigates the initiation and progression of gastrointestinal cancers, particularly colorectal cancer and esophageal adenocarcinoma. It focuses on understanding the role of precancerous lesions and the surrounding tissue environment in cancer development. By studying molecular changes and tumor-promoting mechanisms, the research aims to identify new strategies for cancer prevention and early detection. Patients may benefit from insights that could lead to improved screening and treatment options for these cancers.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and early detection methods for gastrointestinal cancers, potentially saving lives.
How similar studies have gone: Previous research has shown promise in understanding the molecular mechanisms of cancer progression, indicating that this approach could yield valuable insights.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Yu, Ming — Fred Hutchinson Cancer Center
- Study coordinator: Yu, Ming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.