Investigating new genetic factors that influence gastrointestinal cancer and immune response.
Official title: Functional characterization of novel oncogenic loci driving progression and immune response in gastrointestinal cancer
Funded at University of Tx Md Anderson Can Ctr · NIH-10892278 · Data updated 2026-11-12
This study is looking at how certain genetic changes in gastrointestinal cancer can affect the immune system's ability to fight the disease, with the goal of finding new treatment options that are better suited for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00CA263014-04 |
| Project ID | NIH-10892278 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with gastrointestinal cancer, particularly those who have not responded well to existing treatments.
✕Less likely to help
Patients with non-gastrointestinal cancers or those who are not currently undergoing treatment for cancer may not benefit from this research.
What this research studies
This research focuses on understanding how specific genetic changes contribute to the progression of gastrointestinal cancer and how these changes affect the immune system's ability to fight the disease. By utilizing advanced genomic sequencing and innovative laboratory techniques, the study aims to identify novel oncogenes that could be targeted for new therapies. The research also explores the mechanisms by which tumors evade immune detection, which is crucial for developing effective immunotherapies. Patients may benefit from insights that could lead to more effective treatment options tailored to their specific cancer profiles.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and personalized treatments for gastrointestinal cancer.
How similar studies have gone: Previous research has shown promise in targeting oncogenes and utilizing immunotherapy in cancer treatment, indicating that this approach may yield significant advancements.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Lo, Yuan-Hung — University of Tx Md Anderson Can Ctr
- Study coordinator: Lo, Yuan-Hung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.