Translational science to understand how GI cancers start and grow in Barrett’s esophagus
Official title: Translational Science of Gastrointestinal Cancer Initiation and Progression
Funded at Fred Hutchinson Cancer Center · NIH-11395527 · Data updated 2026-11-12
This grant looks at how Barrett’s esophagus may lead to esophageal cancer and colorectal cancer and what early signs could hint at cancer forming.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 19, 2018 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $345,951 |
| NIH project number | 5R50CA233042-10 |
| Project ID | NIH-11395527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with Barrett’s esophagus or colorectal precancerous lesions may be eligible for related studies or future trials.
✕Less likely to help
People without GI precancerous conditions may not directly benefit from this research.
What this research studies
If funded, researchers will study how normal GI tissue becomes cancerous, focusing on Barrett’s esophagus and related lesions. The project will combine lab models and patient data to trace the sequence from early lesions to cancer and identify factors in the surrounding tissue that promote tumors. The goal is to uncover early markers and mechanisms that could lead to better prevention and early detection.
Why it matters
Potential benefit: If successful, findings could lead to earlier detection methods and prevention strategies for Barrett’s-related esophageal cancer and colorectal cancer.
How similar studies have gone: Previous work suggests the tumor environment influences cancer progression, supporting a potential benefit from this approach.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Yu, Ming — Fred Hutchinson Cancer Center
- Study coordinator: Yu, Ming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.