NIH-funded research R21 grant

Gut microbiome and multisensory sensitivity in teen menstrual pain

Official title: Gut Microbiome Mechanisms of Multisensory Sensitivity in Primary Dysmenorrhea

Funded at Mclean Hospital · NIH-11438140 · Data updated 2026-11-12

A study in adolescent girls with moderate-to-severe menstrual pain will explore how gut bacteria relate to their pain and sensitivity to different senses.

More Gut Microbiome research and trials

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionMclean Hospital
NIH-funded
Lab location1 site (Belmont, United States)
Project startSeptember 5, 2026
Project endAugust 31, 2028
Funding year2026
Award (this year)$468,368
NIH project number1R21HD123315-01
Project IDNIH-11438140 on NIH RePORTER

Who could benefit from this research

Could help

Adolescent girls aged 13–19 with moderate-to-severe primary dysmenorrhea.

Less likely to help

Teens without menstrual pain or with non-primary causes may not benefit.

What this research studies

This project looks at whether the gut microbiome is connected to multisensory sensitivity and menstrual pain in girls aged 13–19 with primary dysmenorrhea. It will collect gut bacteria data, sensory responsiveness, and pain measures to understand potential links. The findings could point to new ways to manage menstrual pain by considering gut health and sensory processing. If successful, the study may lay the groundwork for future trials and personalized approaches for adolescents dealing with chronic menstrual pain.

Why it matters

Potential benefit: If successful, results could lead to new, gut-focused strategies to reduce menstrual pain and sensory sensitivity in teens.

How similar studies have gone: Prior research links gut microbiome to chronic pain and sensory processing, but this specific connection in adolescent dysmenorrhea is new.

Where this research is happening

  • Mclean Hospital
    Belmont, United States
    Active

Researchers

  • Principal investigator: Payne, Laura a — Mclean Hospital
  • Study coordinator: Payne, Laura a

Related research

Other NIH-funded projects on the same topics.

  • Understanding menstrual pain and its effects on adolescent girls

    This study is looking at menstrual pain in girls aged 14-18 to find out what might predict if they will develop long-lasting pain, using tests and brain scans to understand how their bodies handle pain, with the hope of improving treatment options in the future.

    NIH research Mclean Hospital · Belmont, United States · NIH-10624359

  • Multi-agent AI to annotate enzymes in the human gut microbiome

    A team at a major university will build an AI system that automatically curates and labels the functions of enzymes in the human gut microbiome to speed up understanding their health effects.

    NIH research University of South Florida · Tampa, United States · NIH-11594384

  • Mapping how gut bacteria transform drugs

    Scientists will study how the gut microbiome changes thousands of drugs into new forms, which could affect how well a medicine works or whether it causes side effects.

    NIH research Stanford University · Stanford, United States · NIH-11550022

  • Aflatoxin exposure and child growth in Guatemala

    A study in rural Guatemala will track how exposure to aflatoxin relates to growth and gut health in young children.

    NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11513260

  • Gut bacteria that can make cancer immunotherapy less effective

    This project will see if reducing chronic inflammation driven by certain gut bacteria can help immunotherapy work better for people whose cancers have stopped responding.

    NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11478145

  • How gut bacteria affect how cancer drugs work

    This project looks at how the bacteria in your gut might change how well and with what side effects fluoropyrimidine cancer drugs like 5-FU work in people.

    NIH research University of California, San Francisco · San Francisco, United States · NIH-11473234

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.