Condition

Drug Use clinical trials and research

• 11Clinical trials
• 93NIH research projects
• 7Countries

Newest Drug Use clinical trials

All recruiting trials (11)

• Project REACH: Telehealth at syringe service programs to help people who use drugs access HIV-related care

  A telehealth program at syringe service sites will try to connect adults who use drugs with HIV-related services to see if it is feasible and acceptable and may help them get care.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07433712

• Online program to support families of LGBTQ youth

  This study is testing an online program to help families of LGBTQ youth understand and support their children better, especially those from diverse backgrounds.

  Recruiting Phase 2 University of Michigan · Ann Arbor, Michigan · NCT06839859

• Rapid-start HIV treatment to reduce stigma for people who inject drugs

  This project will test whether starting HIV treatment quickly (within 7 days) reduces stigma and improves care for people who inject drugs, including those in prison.

  Recruiting at 2 sites Yale University · Kajang and 2 other locations · NCT06541028

• Combination treatment for advanced pancreatic cancer

  This study is testing a new combination of treatments for people with advanced pancreatic cancer who haven't had treatment before to see if it helps manage their disease better.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06405490

• Low dead-space syringe and needle distribution for people who inject drugs in low- and middle-income countries

  This program will test whether offering low dead-space syringes and needles to people who inject drugs at needle and syringe programs in several low- and middle-income countries increases acceptability and use of safer injecting equipment.

  Recruiting at 9 sites Médecins du Monde · Yerevan and 8 other locations · NCT06395129

• Syringe-service telemedicine plus social-network HIV prevention program

  This program will test whether training people who inject drugs to recruit and educate their peers through syringe service telemedicine and social networks increases HIV testing and use of prevention and treatment services in Maryland.

  Recruiting Johns Hopkins University · Baltimore, Maryland and 1 other locations · NCT06103370

• Parenting intervention for Hispanic sexual minority youth

  This study tests a new parenting program designed to help Hispanic teens who identify as gay, lesbian, or bisexual by reducing drug use and depression through better family support and acceptance.

  Recruiting University of Miami · Coral Gables, Florida · NCT06057337

• Assessing harm reduction services for drug users

  This study is testing a new approach to help Black and Latinx individuals who use drugs get better support and services compared to the usual options.

  Recruiting at 2 sites NYU Langone Health · New Haven, Connecticut and 2 other locations · NCT05776316

• Improving mental health for Hispanic adolescents in primary care

  This study is testing a new online program called Familias Unidas to see if it can help Hispanic teens aged 12 to 16 feel less depressed, anxious, and suicidal while getting support from their families.

  Recruiting at 6 sites University of Miami · Miami, Florida and 16 other locations · NCT05426057

• Comparing morning and bedtime dosing of blood pressure medication

  This study is testing whether taking blood pressure medication in the morning or at bedtime works better to lower blood pressure in people with high blood pressure who haven't been treated before.

  Recruiting Phase 4 Shanghai Institute of Hypertension · Shanghai, Shanghai Municipality · NCT05089448

• Reducing drug-related readmissions in older patients with pharmacist support

  This study tests if extra support from pharmacists can help older patients over 75 avoid going back to the hospital due to medication problems.

  Recruiting Umeå University · Umeå · NCT03671629

NIH-funded research (newest 40 of 93)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Couples-based motivational interviewing to reduce drug use and HIV risk in vulnerable male couples

  A couples-focused program helps at-risk male couples reduce drug use and HIV risk together.

  NIH research Hunter College · New York, United States · NIH-11551196

• How growing up poor in rural Georgia affects children's brains and risk for drug use

  This project looks at how early poverty and stress in rural Georgia change children's brain systems and their later chances of using drugs.

  NIH research University of Georgia · Athens, United States · NIH-11482288

• Understanding why teens relapse after treatment and how to keep them safe

  A teen-focused study will look at why adolescents who finish inpatient treatment sometimes return to high-risk drug use and how that affects overdose risk.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11447491

• Peer-led intervention to spread overdose prevention and support quitting opioids in high-risk communities

  A randomized trial will test a peer-education program to reduce overdoses and help people who use opioids start or stay in treatment, by using social networks and new withdrawal-focused strategies.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11422050

• High-Dose Medications for Opioid Use Disorder and Retention in Care

  This project tests whether adjusted, higher-dose MOUD regimens can help people stay in treatment and reduce overdose risks during the fentanyl crisis.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11422040

• OVAL: How laws about drug use in pregnancy affect pregnant and new mothers who use drugs

  A nationwide project is looking at how laws about drug use in pregnancy influence health for pregnant and postpartum women who use drugs.

  NIH research Morehouse School of Medicine · Atlanta, United States · NIH-11415769

• Understanding how early life stress affects adolescent drug risk using brain data

  This project looks at how stressful experiences in early life shape brain systems and behaviors that influence teen risk for drug use.

  NIH research University of Georgia · Athens, United States · NIH-11402669

• Overdoses in pregnancy and postpartum: how laws about drug use affect care

  This project looks at how state laws about drug use during pregnancy affect overdose risk and access to treatment for pregnant and new mothers who use drugs.

  NIH research Morehouse School of Medicine · Atlanta, United States · NIH-11400943

• Virtual SBIRT for teens and young adults in pediatric primary care

  A telehealth program tests a centralized, quick-access SBIRT approach to screen and connect teens and young adults with help for alcohol and other drug use in pediatric primary care clinics.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11400392

• Motivational Interviewing and Mindfulness-Only Recovery for Tobacco and Other Drug Use in Methadone Treatment

  A new program combines motivational interviewing and mindfulness-based therapy to help people on methadone treatment quit tobacco and other drugs at the same time.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11382249

• Couples-based motivational interviewing to reduce drug use and HIV risk in vulnerable male couples

  A couples-centered counseling approach helps two men in a relationship reduce drug use and lower HIV risk together.

  NIH research Hunter College · New York, United States · NIH-11378180

• Propensity scores and drug use in older adults

  This grant aims to improve how we study how medicines and vaccines work for people aged 65 and up by refining methods to account for other health factors in real-world data.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11373009

• Mindfulness and motivational coaching to help people on methadone quit smoking and reduce other drug use

  This program offers group mindfulness training plus motivational coaching for people on methadone to help them stop smoking and cut down other drug use.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11364696

• Metacognition problems predicting opioid addiction outcomes

  This research looks at how people with opioid use disorder think about their own thinking and whether these metacognition issues relate to drug use and quality of life.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11364616

• Cellphone-based intervention to prevent drug use among youth experiencing homelessness

  A mobile-program aims to help homeless youth manage emotions and coping in ways that reduce alcohol and drug use.

  NIH research University of Nebraska Lincoln · Lincoln, United States · NIH-11358301

• How Prenatal Drug Laws Affect Mothers, Babies, and Care

  This project looks at how state laws about prenatal drug use influence health outcomes for pregnant people, newborns, and families.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11357979

• How drug-use networks affect who uses overdose prevention programs

  This project looks at how friends, peers, and other drug-use networks influence whether people use overdose prevention programs and related services.

  NIH research Brown University · Providence, United States · NIH-11354932

• Striosome circuits and costly drug use

  A research project from the University of Texas El Paso explores how brain circuitry related to cost and reward influences cocaine use, with the goal of better understanding why people might keep taking drugs even when it costs them.

  NIH research University of Texas El Paso · El Paso, United States · NIH-11345947

• Motivational interview approach to boost use of drug checking and safer drug use to prevent overdoses

  A community-based program led by peers uses a brief motivational interview to help people who use drugs use drug-checking services more and adopt safer behaviors to reduce overdoses in San Diego.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11333034

• Online group program to help women with recent incarceration reduce drug use and use contraception

  An online group program using video calls and interactive activities to help reproductive-aged women with recent histories of incarceration cut down on drug use and start or increase use of birth control.

  NIH research Fairleigh Dickinson University · Teaneck, United States · NIH-11326197

• Metformin to help immune balance in people with HIV or at risk, who have a history of injection drug use

  A study tests whether metformin can help restore immune balance in people living with HIV or at risk for HIV who have a history of injection drug use.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11322090

• Keeping teens from starting or increasing alcohol, vaping, or marijuana use during the move from high school to adulthood

  An online program for high school seniors that teaches practical skills and changes social norms to help prevent drinking, vaping, and marijuana use as you graduate and move into young adulthood.

  NIH research Prevention Strategies, LLC · Greensboro, United States · NIH-11322057

• Trends in drug, alcohol, and tobacco use among American youth

  Annual national surveys track substance use and related behaviors among U.S. students and follow groups of graduates into adulthood.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11312730

• Tracking substance use across adulthood (ages 19–65)

  This project follows people from age 19 to 65 with web surveys to learn how drug, alcohol, and tobacco use changes over time.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11312577

• Sibling social influences on teen and young adult drinking and drug use

  Young people’s choices about drinking and drug use are shaped by their brothers and sisters, not just their own peers or genetics.

  NIH research Utah State University · Logan, United States · NIH-11297488

• Early hardship and drug-use risk in low-income rural children

  This project looks at how hardships in early childhood affect brain development and later risk for drug use in low-income rural children starting at age seven.

  NIH research University of Georgia · Athens, United States · NIH-11261225

• Making it easier to collect social and drug-use network information for people affected by HIV

  This project is building a user-friendly, cloud-based tool to help researchers collect social and drug-use network information from people at risk for or living with HIV so prevention efforts can better reach them.

  NIH research Northwestern University · Chicago, United States · NIH-11257713

• SmartAI Drive Safety Tool for Real-Time Drug-Use Detection

  A real-time, AI-powered mobile app helps drivers check if they might be under the influence of non-disordered drugs before they drive, with a focus on school and college bus drivers.

  NIH research Tibbling Technologies LLC · Redmond, United States · NIH-11239715

• Digital tools to support care for people with serious mental illness and related drug use

  A software platform is being built to help care teams, patients, and families coordinate and practice realistic appointment conversations to better manage serious mental illness and associated substance use.

  NIH research Doro Mind INC. · Albany, UNITED STATES · NIH-11239321

• DRhQ: a new approach to protect brain cells after drug-related injury by targeting CD74 signaling

  A new treatment called DRhQ aims to reduce brain damage from non-disordered drug use, using a molecule that calms inflammation and supports white-matter health in affected individuals.

  NIH research Virogenomics Biodevelopment, INC. · Tigard, UNITED STATES · NIH-11237537

• How early life challenges affect drug use risk in rural children

  This study looks at how growing up in low-income rural areas affects children's brain development and their chances of misusing drugs, focusing on kids from rural Georgia and following them from age 7 to see how their environment shapes their thinking and feelings.

  NIH research University of Georgia · Athens, United States · NIH-11233548

• Investigating metformin's effects on immune health in people with and without HIV who use injection drugs

  This study is looking at how the diabetes medication metformin might help improve the immune system in people living with HIV and those who use injectable drugs, by reducing inflammation and boosting certain immune cells, to help lower their risk of infections and other health problems.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11195633

• Understanding how costs affect drug use and cravings

  This study is looking at how cravings for drugs and the costs of using them affect people's choices, especially when stress or aging comes into play, to help find better ways to treat addiction.

  NIH research University of Texas El Paso · El Paso, United States · NIH-11184256

• Using peer support to encourage safer drug use and reduce overdoses

  This study is testing a friendly program called MI-CHANCE that helps people who use drugs learn about safer practices and encourages them to use drug checking services, especially for Latinx individuals who might have trouble accessing these resources, all with the goal of reducing overdose incidents over two and a hal

  NIH research University of California, San Diego · La Jolla, United States · NIH-11180417

• Understanding the Impact of State Laws on Prenatal Drug Use

  This project looks at how different state laws about drug use during pregnancy affect the health and well-being of pregnant people, new mothers, and their babies.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11170370

• Telehealth screening and brief counseling for teen alcohol and drug use

  A telehealth program that provides quick screening, brief counseling, and referrals for teens in pediatric primary care who use alcohol or drugs.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11162328

• Identifying brain markers for addiction cravings and drug use

  This study is looking to find new ways to measure brain signals that can help us understand and predict cravings for substances like cocaine, alcohol, and tobacco, which could lead to better support for people dealing with addiction.

  NIH research University of California Berkeley · Berkeley, United States · NIH-11161100

• Connections between HIV, gut bacteria, and drug use

  Using large genetic datasets, researchers will look for links between drug use, gut microbes, immune changes, and the chance of getting HIV to help people affected by HIV and substance use.

  NIH research Yale University · New Haven, United States · NIH-11145110

• Early life stress and teen brain changes linked to drug risk

  Looks at how early life stress and brain development relate to drug use risk in teens.

  NIH research University of Georgia · Athens, United States · NIH-11141876

• How genes and biological pathways interact to influence cannabis and alcohol problems

  This project looks at how combinations of genes and biological pathways relate to cannabis and alcohol use problems to help explain who is at higher risk.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11136539

Related topics

Quick answers

How many Drug Use clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (6 trials), China (2 trials), Armenia (1 trial), Georgia (1 trial), Tanzania (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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