Metacognition problems predicting opioid addiction outcomes
Official title: Metacognition circuit impairments predicting drug use and quality-of-life in human opioid addiction
Funded at State University New York Stony Brook · NIH-11364616 · Data updated 2026-11-12
This research looks at how people with opioid use disorder think about their own thinking and whether these metacognition issues relate to drug use and quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | June 1, 2026 |
| Project end | February 28, 2031 |
| Funding year | 2026 |
| Award (this year) | $716,669 |
| NIH project number | 1R01DA062644-01A1 |
| Project ID | NIH-11364616 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with opioid use disorder who are willing to participate in longitudinal brain imaging and cognitive testing.
✕Less likely to help
Individuals without OUD or those unable to participate in long-term follow-up or MRI procedures may not benefit.
What this research studies
The project follows people with opioid use disorder over time to see if they have metacognitive gaps, such as over- or underestimating their performance on cognitive tasks, and whether these gaps relate to brain activity in the anterior prefrontal cortex. It builds on earlier findings to confirm metacognitive underconfidence and its connection to illicit opioid use and quality of life. The study uses longitudinal data and brain imaging to connect cognitive self-awareness with real-world outcomes, aiming to identify potential targets for treatment. Results could help tailor interventions that address both cognitive function and daily living quality for people in recovery.
Why it matters
Potential benefit: If successful, it could lead to new approaches that improve self-awareness of thinking errors and support better treatment outcomes for opioid use disorder.
How similar studies have gone: Previous work showed metacognitive deficits in OUD and links to brain function, supporting potential for meaningful findings in this longitudinal study.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Moeller, Scott J — State University New York Stony Brook
- Study coordinator: Moeller, Scott J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.