NIH-funded research R01 grant

Keeping teens from starting or increasing alcohol, vaping, or marijuana use during the move from high school to adulthood

Official title: Preventing Drug Use Onset and Progression toward Addiction during a CriticalTransition Period: Optimizing an Online Intervention for High School Seniors

Funded at Prevention Strategies, LLC · NIH-11322057 · Data updated 2026-11-12

An online program for high school seniors that teaches practical skills and changes social norms to help prevent drinking, vaping, and marijuana use as you graduate and move into young adulthood.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionPrevention Strategies, LLC
NIH-funded
Lab location1 site (Greensboro, United States)
Project startJuly 15, 2024
Project endApril 30, 2029
Funding year2026
Award (this year)$549,618
NIH project number5R01DA058697-03
Project IDNIH-11322057 on NIH RePORTER

Who could benefit from this research

Could help

Ideal participants are high school seniors (12th graders) approaching graduation, including both future college students and nonstudents who want help avoiding alcohol, vaping, or marijuana.

Less likely to help

People who already have an established substance use disorder or who are well past the transition age are unlikely to get benefit from this prevention-focused program.

What this research studies

You would be invited to try an online program designed just for high school seniors during the transition out of high school. The program focuses on changing what peers think is normal and teaches bystander and protective strategies to resist substance use. Designers will use human-centered feedback and iterative testing to make the program engaging and useful for students like you. The team aims to create a scalable, widely available intervention that also addresses vaping and other common young-adult substance risks.

Why it matters

Potential benefit: If successful, this program could reduce the number of teens who start or increase substance use after graduation and lower future addiction risk.

How similar studies have gone: Norms-based and protective-strategy programs have reduced substance use among college students, but applying and optimizing these approaches specifically for high school seniors and nonstudents is relatively new.

Where this research is happening

  • Prevention Strategies, LLC
    Greensboro, United States
    Active

Researchers

  • Principal investigator: Rulison, Kelly Lin — Prevention Strategies, LLC
  • Study coordinator: Rulison, Kelly Lin

Related research

Other NIH-funded projects on the same topics.

  • Metacognition problems predicting opioid addiction outcomes

    This research looks at how people with opioid use disorder think about their own thinking and whether these metacognition issues relate to drug use and quality of life.

    NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11364616

  • Optimizing an online program to prevent substance use in high school seniors

    This study is creating an online program to help high school seniors avoid using alcohol, tobacco, and marijuana during the important time right after graduation, by making it fun and relatable for them.

    NIH research Prevention Strategies, LLC · Greensboro, United States · NIH-11134691

  • Improving methods to handle missing data in addiction research

    This study is looking at new ways to handle missing information in research about drug use and addiction, using real-time surveys to better understand people's behaviors and the reasons behind them, so we can improve support and treatment for those facing addiction.

    NIH research University of Rhode Island · Kingston, United States · NIH-11093988

  • Understanding how stress affects drug use in people with opioid addiction

    This study is looking at how stress affects people with opioid use disorder who are trying to overcome their addiction, to help improve their treatment and reduce the chances of relapse.

    NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11012796

  • Reducing Addiction Risk in High Schools Through Better Prevention Infrastructure

    Aims to build a sustainable, school-based system to prevent opioid and other drug use among high school students, especially those at higher risk.

    NIH research Washington University · Saint Louis, United States · NIH-11582595

  • HEAL Data Platform to share addiction-related data across programs

    A platform project to make HEAL data from many programs easier to find and use, helping researchers and clinicians access information about addiction in children and youth.

    NIH research University of Chicago · Chicago, United States · NIH-11580283

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.