Condition

Chronic Rhinosinusitis (CRS) clinical trials and research

• 10Clinical trials
• 2NIH research projects
• 8Countries

Newest Chronic Rhinosinusitis (CRS) clinical trials

All recruiting trials (10)

• Triamcinolone-loaded nanocapsules after endoscopic nasal surgery

  This trial tests whether a triamcinolone acetonide–loaded nanocapsule spray is better than saline irrigation for healing after endoscopic nasal surgery in adults with chronic rhinosinusitis and nasal polyps.

  Recruiting Phase 2 Deraya University · Minya, Menia Governorate · NCT07714525

• Smell training in CRS patients with smell loss

  This study tests whether a 3-month smell training program can improve smell function and related immune and mental health measures in adults with chronic rhinosinusitis and smell loss.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07681973

• PROPEL corticosteroid‑releasing sinus implants — IBUKI cohort

  This project tests how safe and well PROPEL corticosteroid‑releasing sinus implants work for people in Japan with chronic rhinosinusitis who undergo endoscopic sinus surgery.

  Recruiting Medtronic · Asahikawa · NCT07546682

• Lavender aromatherapy for anxiety and pain during awake ear, nose, and throat procedures

  This tests whether lavender aromatherapy used during awake ear, nose, and throat clinic procedures can reduce anxiety and pain in adults.

  Recruiting Cedars-Sinai Medical Center · Los Angeles, California · NCT07299474

• Seawater nasal sprays for relief of nasal and sinus symptoms

  This project will test four seawater nasal sprays to see if they help infants, children, adults, and pregnant or breastfeeding people with acute or chronic nasal and sinus symptoms.

  Recruiting at 32 sites Laboratoire de la Mer · Bordeaux and 31 other locations · NCT07262450

• VVN432 nasal spray safety and early testing in healthy adults and people with chronic rhinosinusitis

  This will test whether VVN432 nasal spray is safe and how the body processes it in healthy adults and in people with chronic rhinosinusitis.

  Recruiting Phase 1 VivaVision Biotech, Inc · Beijing · NCT07259538

• Stopping or continuing nasal rinses and topical nasal medicines for adults with cystic fibrosis on modulator therapy

  This project will see if adults with cystic fibrosis who are taking highly effective modulator therapy can safely stop nasal rinses and topical nasal steroid or antibiotic treatments without making sinus inflammation worse.

  Recruiting Phase 3 Indiana University · Indianapolis, Indiana · NCT06996951

• Comparing therapeutic ultrasound and sinus massage for chronic rhinosinusitis

  This study is testing whether therapeutic ultrasound or sinus massage can help people with chronic rhinosinusitis feel better and improve their quality of life.

  Recruiting Foundation University Islamabad · Islamabad · NCT06960876

• Comparing Penthrox to placebo for pain relief in sinus procedures

  This study is testing if inhaling Penthrox can help people feel less pain during minor sinus procedures compared to a placebo.

  Recruiting Phase 1/2 St. Paul's Hospital, Canada · Vancouver, British Columbia · NCT06750302

• Evaluating the effectiveness of biologics for chronic rhinosinusitis with nasal polyps

  This study is testing how well biologic treatments work for adults with chronic rhinosinusitis and nasal polyps to see if they are more effective than standard treatments.

  Recruiting at 8 sites Universitaire Ziekenhuizen KU Leuven · Aalst and 7 other locations · NCT06683261

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• AI-guided personalized care for chronic sinus inflammation

  Using AI to personalize treatments for adults with chronic sinus inflammation so people get the therapies most likely to relieve their symptoms.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11249223

• Using AI to create personalized treatments for chronic rhinosinusitis.

  This study is looking at how we can use artificial intelligence to create personalized treatment plans for people with chronic rhinosinusitis (CRS) to help improve their symptoms and overall health.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11023120

Related topics

Quick answers

How many Chronic Rhinosinusitis (CRS) clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (3 trials), France (1 trial), Belgium (1 trial), Egypt (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 1: 1, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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