Oropharyngeal suction and physiotherapy to detect lung bacteria in kids with chronic lung disease
Official title: Diagnostic Value of Oropharyngeal Suction Compared With Induced Sputum and Oropharyngeal Swab, and the Effect of Respiratory Physiotherapy on the Detection of Microorganisms in Paediatric Patients With Chronic Respiratory Disease: a Randomized Clinical Trial
Run by Corporacion Parc Tauli · NCT07903792 · Data updated 2026-11-12
A randomized study will test whether taking samples from the throat with suction, with or without prior physiotherapy, can reliably detect bacteria in children 5–18 with chronic lung disease, compared with standard sample methods.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 5 Years to 18 Years |
| Sex | All |
| Enrollment | 196 (estimated) |
| Sponsor | Corporacion Parc Tauli Academic / other |
| Locations | 1 site (Sabadell, Barcelona) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | June 2028 |
| Study ends | June 2028 |
| Registry record updated | October 29, 2026 |
| Trial ID | NCT07903792 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children aged 5–18 with chronic respiratory disease who require sputum sampling and can cooperate with physiotherapy.
✕Probably not a fit
Patients unable to undergo physiotherapy or sample collection, or with severe acute illness, may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, parallel-group study compares respiratory sampling methods in children aged 5 to 18 with chronic lung disease. It evaluates the diagnostic performance of oropharyngeal suction against induced sputum and oropharyngeal swabs for detecting respiratory microorganisms, and whether a physiotherapy session before sampling improves results. The study also explores how age subgroups affect sampling accuracy and safety. Participants undergo sampling with and without prior physiotherapy, using oropharyngeal suction, induced sputum, and oropharyngeal swabs, to determine agreement among methods and overall diagnostic value.
Why it matters
Potential benefit: If successful, the approach could provide a simpler or more tolerable way to detect respiratory pathogens in children with chronic lung disease.
How similar studies have gone: Previous work has explored sampling methods like induced sputum and throat swabs, with varying diagnostic concordance; this study tests a novel combination and timing (with/without physiotherapy).
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Having a chronic respiratory disease that requires sputum sample collection. * Being able to cooperate during the physiotherapy session. * Having provided signed informed consent. Exclusion Criteria: * Severe acute infection that contraindicates any of the procedures (e.g., severe respiratory failure, shock, etc.). * Having taken antibiotics in the previous week, except for patients receiving chronic azithromycin treatment. * Decompensated cardiorespiratory disease. * History of severe adverse reactions to hypertonic saline nebulization. * Patients who do not consent to or are unable to undergo the procedures.
Where it's running
-
Corporació Sanitària Parc Taulí
Sabadell, Barcelona, Spain Recruiting
Study contacts
- Study coordinator: Alba Valls-Llovera
- Email: avallsl@tauli.cat
- Phone: +34644253942
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.