Improving lung function in children with cystic fibrosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to implement a quality improvement plan to achieve a 5% increase in the Forced Expiratory Volume in 1st second (FEV1) in pediatric patients with cystic fibrosis over a 12-month period. The study will involve 35 children aged 6 to 18 years who have impaired pulmonary function. Participants will be monitored at a specialized clinic where a multidisciplinary team will develop and adjust individualized treatment plans based on standardized care algorithms. Serum levels of human epididymis protein 4 (HE4) will also be measured before and after the intervention to assess its impact on pulmonary function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pediatric CF patients diagnosed based on the Consensus Guidelines from the Cystic Fibrosis Foundation, with a positive sweat chloride test (≥60 milliequivalent/L) and/or the presence of two CF disease-causing gene mutations.
* Age ≥6 years.
* Forced expiratory volume in 1 second (FEV₁) ≤80%.

Exclusion Criteria:

●Patients are unable to perform spirometry.

Where it's running

• Ain Shams university
  Cairo, Abbasia, Egypt Recruiting

Study contacts

• Principal investigator: Eman Fawzy — Ain Shams University
• Study coordinator: Eman Fawzy, MD
• Email: eman199358@gmail.com
• Phone: Egypt: 201011778583

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.