Investigating how lung diseases affect white blood cells in the lungs

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the impact of Alpha-1-antitrypsin deficiency and Cystic Fibrosis on the functionality of lung macrophages, which are crucial white blood cells involved in inflammation and tissue repair. The study will involve participants undergoing a history and physical examination, blood draws, pulmonary function testing, and the use of an albuterol inhaler. By understanding how these conditions impair macrophage function, the research seeks to uncover new insights into the mechanisms behind lung inflammation and disease progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Signed informed consent
* Male or female 18 years of age or older
* Negative pregnancy test for women of childbearing potential
* Hemoglobin \>12.5 g/dl measured on the day of participation
* Negative urine nicotine test

Exclusion Criteria:

* Pregnancy or breastfeeding
* Weight \< 50 kg
* History of anemia requiring blood transfusions, erythropoietin supplementation, or iron supplementation within the past 36 months
* Known hemoglobin \<12.5 g/dl within the past 90 days
* Systolic blood pressure \> 180 mmHg and/or diastolic blood pressure \>100 mmHg
* Poor venous access
* Large volume blood donation (\>200 ml or 7 ounces) within the previous 56 days (e.g. blood donation for the purposes of blood banking)
* Clinically significant cardiac, hemostatic or neurological impairment or any other significant medical condition that, in the opinion of the investigator would affect subject safety (e.g., recent myocardial infarction, history of prolonged bleeding time, cerebral vascular accident, advanced cancer or uncontrolled medical condition)
* Psychiatric or cognitive disturbance or illness that would affect subject safety
* Current smoker

Where it's running

• Shands at the University of Florida
  Gainesville, Florida, United States Recruiting

Study contacts

• Principal investigator: Karina Serban, MD — University of Florida, College of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine
• Study coordinator: Allison E. Faunce, B.A.
• Email: Allison.Faunce@medicine.ufl.edu
• Phone: 352-273-8666

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.