Autogenic Drainage vs. Mechanical Chest Percussion in Children with Cystic Fibrosis
Official title: Comparative Effects of Autogenic Drainage and Mechanical Percussion on Lung Function, Dyspnea and Quality of Life in Children With Cystic Fibrosis
Run by Riphah International University · NCT07729787 · Data updated 2026-11-12
In children aged 6-12 with cystic fibrosis, this study tests whether autogenic drainage helps lung function and comfort more than mechanical percussion.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 6 Years to 12 Years |
| Sex | All |
| Enrollment | 32 (estimated) |
| Sponsor | Riphah International University Academic / other |
| Locations | 1 site (Multan Khurd, Punjab Province) |
| Status | Recruiting |
| Started | June 14, 2026 |
| Main results expected | November 30, 2026 |
| Study ends | November 30, 2026 |
| Registry record updated | July 28, 2026 |
| Trial ID | NCT07729787 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children aged 6-12 with a confirmed CF diagnosis who are clinically stable and able to participate in airway clearance therapy.
✕Probably not a fit
Children who do not respond to autogenic drainage or have contraindications to the therapies may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial compares two airway clearance techniques in CF patients: autogenic drainage and mechanical percussion. Participants are randomly assigned to one technique and receive supervised sessions five times a week for six weeks, with assessments of lung function, breathlessness, and quality of life. The study aims to see which method more effectively improves lung function and reduces dyspnea in pediatric CF patients. The trial is conducted at Nishter Hospital Multan, led by Riphah International University. Eligibility includes confirmed CF, age 6-12, and stable condition without recent pulmonary exacerbations.
Why it matters
Potential benefit: If autogenic drainage proves superior, children with CF might experience better breathing, fewer symptoms, and improved quality of life.
How similar studies have gone: Previous research has explored similar airway clearance methods, but direct comparisons in this age group are limited, making this study relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Confirmed diagnosis of cystic fibrosis (CF) through a sweat test or genetic testing. * Age between 6 and 12 years. * Clinically stable condition (no acute pulmonary exacerbation within the last 4 weeks). Exclusion Criteria: * History of thoracic surgery. * Active hemoptysis. * Severe physical or cognitive disabilities limiting participation in the intervention or assessments.
Where it's running
-
Nishter Hospital Multan
Multan Khurd, Punjab Province, Pakistan Recruiting
Study contacts
- Principal investigator: Humera Ayub, MS-CPPT — Riphah International University
- Study coordinator: Imran Amjad, PhD
- Email: imran.amjad@riphah.edu.pk
- Phone: 03324390125
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Oropharyngeal suction and physiotherapy to detect lung bacteria in kids with chronic lung disease
A randomized study will test whether taking samples from the throat with suction, with or without prior physiotherapy, can reliably detect bacteria in children 5–18 with chronic lung disease, compared with standard sample methods.
-
Seeing if CFTR functioncan be restored in CF through patient cells with rare mutations
This study tests whether testing a patient’s own nasal cells in the lab can predict if CFTR-modulator therapies might help people with uncommon CF mutations.
-
Perceptions and Intentions Around a Change in CF Treatment
This study asks adults with cystic fibrosis currently on ETI whether they would switch to VTD if their doctor offered it and what factors influence that decision.
-
How the CF medicines elexacaftor, tezacaftor, and ivacaftor behave in the body
This study tests how the CF medicines elexacaftor, tezacaftor, and ivacaftor move through the body in patients with cystic fibrosis who are already taking the combination therapy.
-
Pharmacokinetics of Antibiotics in CF Patients on ETI
This study tests how antibiotics behave in the body of people with cystic fibrosis who are taking the ETI modulator therapy and are being treated for a pulmonary infection.
-
Proof of principle for linaclotide to improve gut symptoms in cystic fibrosis
This will test whether linaclotide can increase intestinal fluid and ease constipation and abdominal symptoms in adults with cystic fibrosis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.