Understanding the genetic changes in skin cancer
The genomic landscape and evolution of cutaneous squamous cell carcinoma
This study is looking at how certain genetic changes in skin cells can turn a harmless skin condition into squamous cell carcinoma, a type of skin cancer, to help find better ways to diagnose and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10914884 on NIH RePORTER |
What this research studies
This research investigates cutaneous squamous cell carcinoma, a type of skin cancer, by analyzing the genetic mutations that drive its development. The team will collect and analyze genetic data from both cancerous lesions and their benign precursors, known as actinic keratoses, to understand how these mutations evolve over time. By sequencing the genomes of these lesions, the researchers aim to identify key mutations that contribute to the transition from benign to malignant states. This comprehensive approach will help in mapping the genetic landscape of this cancer and could lead to improved diagnostic and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cutaneous squamous cell carcinoma or those with actinic keratoses.
Not a fit: Patients with other types of skin cancers or those without any skin lesions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with cutaneous squamous cell carcinoma.
How similar studies have performed: Previous research has shown success in understanding genetic mutations in other cancers, suggesting that this approach could yield valuable insights for cutaneous squamous cell carcinoma as well.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Shain, Alan Hunter — University of California, San Francisco
- Study coordinator: Shain, Alan Hunter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.