Understanding Twist1 to Prevent and Treat Skin Cancer
Twist1 as a Target for Prevention and Treatment of Cutaneous Squamous Cell Carcinoma
This work explores how a protein called Twist1 contributes to squamous cell skin cancer and aims to find new ways to stop or treat this disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-11092757 on NIH RePORTER |
What this research studies
We are looking closely at a protein called Twist1, which seems to play a role in how skin cancer develops and spreads. Our goal is to understand exactly how Twist1 works in squamous cell carcinoma, a common type of skin cancer. By learning more about this protein, we hope to discover new strategies for both preventing skin cancer from forming and for treating it effectively. This could lead to better options for patients facing this condition.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals at risk for or diagnosed with cutaneous squamous cell carcinoma in the future.
Not a fit: Patients seeking immediate treatment options or direct clinical participation would not find direct benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new medications or approaches that prevent the development of squamous cell skin cancer or improve its treatment.
How similar studies have performed: Previous laboratory findings suggest Twist1 is involved in cancer progression, but its specific role in UV-related skin cancer and targeted therapies are still being explored.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Digiovanni, John — University of Texas at Austin
- Study coordinator: Digiovanni, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.